Primary Cancer Sites and Clinical Features of Choroidal Metastasis in Mexican Patients

Figures & data

Table 1 Comparison of Primary Cancer Sites in Different Cohorts

Rank	Current study	Shields et al^Citation12 (2018)	Kreusel et al^Citation10 (2003)	Soysal HG^Citation11 (2007)
1	Breast: 27(34.6%)	Breast: 416 (37.4%)	Breast: 38 (53%)	Breast: 24 (85.7%)
2	Lung: 19 (24.3%)	Lung: 295 (26.5%)	Lung: 19 (26%)	Lung: 2 (7.1%)
3	Unknown: 8 (10.2%)	Unknown: 177 (15.9%)	Others: 6 (8%)	Ovary: 1 (3.6%)
4	GI: 7 (8.9%)	Renal: 46 (4.1%)	Renal: 2 (3%)	GI: 1 (3.6%)
5	Renal: 5 (6.4%)	GI: 40 (3.6%)	GI (Colon): 2 (3%)
6	Testicular: 3 3.8%)	Melanoma: 27 (2.4%)	Melanoma: 2 (3%)
7	Ovary: 3 (3.8%)	Lung carcinoid: 24 (2.1%)	Uveal melanoma: 2 (3%)
8	Prostate: 2 (2.5%)	Prostate: 23 (2.0%)	Unknown: 1 (1%)
9	Thyroid: 2 (2.5%)	Thyroid: 15 (1.3%)
10	Lung carcinoid: 1 (1.2%)	Pancreas: 8 (0.7%)
11	MM: 1 (1.2%)	Others: 40 (3.6%)

Abbreviations: GI, gastrointestinal tract cancer; MM, multiple myeloma.

Table 2 Comparison of Primary Cancer Site Against Sex

Rank	Female Patients		Male Patients
	Current study	Shields et al^Citation12 (2018)	Salcedo-Villanueva et al	Shields et al^Citation12 (2018)
1	Breast: 27 (62%)	Breast: 413 (57.7%)	Lung: 17 (48.5%)	Lung: 164 (41.4%)
2	Unknown: 6 (13.9%)	Lung: 135 (18.8%)	GI: 7 (20%)	Unknown: 91 (22.9%)
3	Ovary: 3 (6.9%)	Unknown: 86 (12.0%)	Testicular: 3 (8.5%)	Renal: 34 (8.5%)
4	Lung: 2 (4.6%)	Others: 22 (3.0%)	Renal: 3 8.3%)	GI: 30 (7.5%)
5	Renal: 2 (4.6%)	Lung carcinoid: 17 (2.3%)	Prostate: 2 (5.7%)	Prostate: 23 (5.8%)
6	Thyroid: 2 (4.6%)	Renal: 12 (1.6%)	Unknown: 2 (5.7%	Melanoma: 19 (4.7%)
7	MM: 1 (2.3%)	GI: 10 (1.3%)	Carcinoid:1 (2.8%)	Others: 18 (4.5%)
8		Melanoma: 8 (1.1%)		Thyroid: 9 (2.2%)
9		Thyroid: 6 (0.8%)		Lung carcinoid: 7 (1.7%)
10		Pancreas: 6 (0.8%)		Pancreas: 2 (0.5%)

Abbreviations: MM, multiple myeloma; GI, gastrointestinal tract cancer.

Table 3 Segmentation of Primary Cancer Site by Age

	Age (SD)	Range	95% CI
Overall Patients N: 78 (100%)	57.62 (14.52)	23–87	54.35–60.94
Breast: 27	56.85 (14.41)	26–87	51.1–62.2
Lung: 19	62.84 (10.39)	43–77	57.82–67.85
Unknown: 8	58 (13.51)	39–79	46.7–69.29
GI tract: 7	56.28 (16.27)	28–80	41.2–71.3
Renal: 5	54.8 (16.09)	35–79	34.8–74.7
Testicular: 3	23.6 (1.15) (P=0.002)	23–25	20.7–26.5
Ovary: 3	56.33 (4.72)	51–60	44.5–68.0
Prostate: 2	67.5 (0.70)	67–68	61.1–73.8
Thyroid: 2	72.5 (13.43)	63–82	−48.2–193.2
Carcinoid: 1	82	—	—
MM: 1	62	—	—

Abbreviations: SD, standard deviation; 95% CI, ninety-five percent confidence intervals; GI, gastrointestinal cancer; MM, multiple myeloma.

Figure 1 (A) Ultra-wide field fundus image of a single lesion, bi-lobulated, dome-shape choroidal metastasis from lung cancer, with intraretinal microhemorrhages over and around the tumor, as well as subretinal fluid in the lower retina quadrants. (B) Choroidal metastasis from breast cancer with multiple, disseminated seeds and a large cystoid subretinal fluid accumulation. (C) Renal cancer metastasis, reddish-orange, slightly elevated and round tumor. (D) Solitary, white-yellowish lesion from pulmonary cancer with subretinal fluid around the metastasis.

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