Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems

Figures & data

Table 1 Components of the Formulation of the Lens Care Systems Evaluated in the Study

	Hydrogen Peroxide-Based Solution	Polyquad/Aldox-Containing Solution
Manufacturer	Alcon Laboratories, Inc.	Alcon Laboratories, Inc.
Disinfecting agent(s)	Micro-filtered 3% Hydrogen peroxide	0.001% Polyquad^a, 0.0005% Aldox^b
Buffers	0.79% sodium chloride and Phosphonic acid, a phosphate buffered system	Sodium chloride, Sodium borate
Chelating agent	—	Sodium citrate
Surfactant/wetting agent(s)	Pluronic 17R4^c, (non-ionic)	Tearglyde (Poloxamine [Tetronic 1304^c], nonanoyl ethylenediaminetriacetic acid); Propylene glycol

Notes: ^aPolyquad, polyquaternium-1; ^bAldox, Myristamidopropyl dimethylamine; ^cRegistered trademark of BASF.

Table 2 Summary of ex vivo Lens Protein Deposition (Mean ± Standard Deviation; Minimum–Maximum in Brackets)

Quantity (Micrograms/Lens)	Hydrogen Peroxide-Based Solution	Polyquad/Aldox-Containing Solution	P value
Total Protein	6.7 ± 2.8	7.3 ± 2.8	0.24
	(1.7–14.7)	(3.6–14.7)
Total Lysozyme	1.3 ± 0.9	1.7 ± 1.0	0.02*
	(0.3–3.8)	(0.5–3.8)
Inactive Lysozyme	0.8 ± 0.7	0.9 ± 0.7	0.09
	(0.2–3.6)	(0.02–2.4)

Note: *Statistically significant.

Abbreviations: Aldox, myristamidopropyl dimethylamine; MPS, multi-purpose cleaning and disinfecting lens care products; Polyquad, polyquaternium-1.