Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infection

Figures & data

Table 1 Demographics and clinical findings of 11 patients with cytomegalovirus and anterior segment inflammation treated with oral valganciclovir

Patient	Gender/age	Diagnosis	Prior surgery	Follow-up duration (months)	Duration of maintenance therapy (months)	Recurrence	Interval between recurrence and stopping valganciclovir therapy (months)	Baseline VA	Final VA	Lines changed	Baseline IOP (mmHg)	Final IOP (mmHg)
1 (OD)	M/60	Endotheliitis	PK, Trab	38	36	Yes	4	20/70	20/800	−12	21	14
1 (OS)	M/60	Endotheliitis	PK, Trab	38	36	No	N/A	20/800	20/70	+12	8	9
2 (OD)	F/50	Endotheliitis	None	13	3.5	No	N/A	20/100	20/40	+4	30	12
2 (OS)	F/50	Endotheliitis	None	13	3.5	No	N/A	20/30	20/20	+2	12	16
3	M/57	Endotheliitis	Trab	24	2	No	N/A	20/1600	20/20	+18	16	17
4	M/59	FUS	None	12	2	Yes	4	20/25	20/20	+1	27	7
5	F/50	FUS	Trab	6	2.5	No	N/A	20/25	20/25	+1	8	8
6	M/49	FUS	None	15	2.5	No	N/A	20/100	20/20	+7	15	8
7	M/48	PSS	None	6	3.5	No	N/A	20/70	20/25	+4	21	17
8	F/39	PSS	None	17	2.5	Yes	1	20/30	20/30	+0	23	16
9	M/58	PSS	Phaco, Trab	23	3.5	No	N/A	20/70	20/800	−12	18	6
10	M/28	PSS	None	6	7	Yes	2	20/20	20/18	+1	11	11
11	M/70	PSS	Phaco	29	27	Yes	1	20/70	20/25	+4	28	11

Abbreviations: M, male; F, female; PSS, Posner-Schlossmann syndrome; FUS, Fuchs uveitis syndrome; PK, penetrating keratoplasty; Trab, trabeculectomy; Phaco, phacoemulsification; VA, visual acuity; IOP, intraocular pressure; N/A, not applicable.

Figure 1 Slit-lamp photos of the left eye of a patient with anterior segment inflammation from cytomegalovirus. (A) Prior to commencement of valganciclovir, there were diffuse multiple pigmented keratic precipitates on the cornea. (B) Four weeks after valganciclovir therapy, the keratic precipitates completed resolved with absence of inflammation in the anterior chamber. (C) One month after stopping valganciclovir therapy, the was recurrence of keratic precipitates on the cornea with mild anterior chamber inflammation. (D) Two weeks after recommencing valganciclovir, the keratic precipitates again resolved with no inflammation in the anterior chamber.