Major single nucleotide polymorphisms in polypoidal choroidal vasculopathy: a comparative analysis between Thai and other Asian populations

Figures & data

Table 1 Demographic characteristic of the study population

	PCV (n = 97)	Controls (n = 102)	P-value
Gender (male/female)	48/49	50/52	0.948a
Mean age ± SD (years)	62.9 ± 8.9	62.2 ± 7.6	0.595b
Age range (years)	42–87	50–86

Notes:

a By z-test;

b by independent t-test.

Abbreviations: PCV, polypoidal choroidal vasculopathy; SD, standard deviation.

Table 2 The allele frequency for each single nucleotide polymorphism in this study and other studies in Asians

	PCV			Controls			P-value	Odds ratio (95% CI)
	N	Ca	T	N	Ca	T
Rs1061170 (Y402H)
Current study	97	29 (15.0%)	165 (85.1%)	102	11 (5.4%)	193 (94.6%)	0.0023	3.081 (1.493–6.360)
Compiled studies	1291	266 (10.3%)	2316 (89.7%)	2455	314 (6.4%)	4596 (93.6%)	<0.0001	2.467 (2.046–2.973)
Gotoh et al^Citation19	204	47 (11.5%)	361 (88.5%)	N/A	N/A	N/A	N/A	N/A
Lee et al^Citation20	72	10 (6.9%)	134 (93.1%)	93	10 (5.4%)	176 (94.6%)	0.6438	1.31 (0.47–3.62)
Kondo et al^Citation13	130	23 (8.8%)	237 (91.2%)	173	18 (5.2%)	328 (94.8%)	0.0770	1.77 (0.93–3.35)
Hayashi et al^Citation9,b	510	106 (10.4%)	914 (89.6%)	1342	176 (6.6%)	2508 (93.4%)	9.73 × 10^−5	N/A
Nakanishi et al^Citation17	375	80 (10.7%)	670 (89.3%)	847	110 (6.5%)	1584 (93.5%)	N/A	N/A
	N	Ga	A	N	Ga	A
Rs800292 (I62V)
Current study	97	139 (71.7%)	55 (28.4%)	102	117 (57.4%)	87 (42.7%)	0.0034	1.879 (1.238–2.854)
Compiled studies	713	1072 (75.2%)	354 (24.8%)	1604	1871 (58.3%)	1337 (41.7%)	<0.0001	2.164 (1.883–2.487)
Lee et al^Citation20	72	109 (75.7%)	35 (24.3%)	93	113 (60.8%)	73 (39.2%)	0.0045	2.01 (1.21–3.36)
Kondo et al^Citation13	130	201 (77.3%)	59 (22.7%)	173	197 (56.9%)	149 (43.1%)	1.7 × 10^−7	2.58 (1.80–3.69)
Hayashi et al^Citation9,b	511	762 (74.6%)	260 (25.4%)	1338	1561 (58.3%)	1115 (41.7%)	N/A	N/A
	N	Ta	G	N	Ta	G
Rs10490924 (A69S)
Current study	97	105 (54.1%)	89 (45.9%)	102	76 (37.3%)	128 (62.8%)	0.0008	1.987 (1.331–2.960)
Compiled studies	747	849 (56.8%)	645 (43.2%)	1331	980 (36.8%)	1682 (63.2%)	<0.0001	2.259 (1.985–2.571)
Kondo et al^Citation18	76	95 (62.5%)	57 (37.5%)	94	71 (37.8%)	117 (62.2%)	5.7 × 10^−6	N/A
Lee et al^Citation20	72	80 (55.6%)	64 (44.4%)	93	72 (38.7%)	114 (61.3%)	0.0027	1.98 (1.24–3.15)
Sakurada et al^Citation21	109	139 (63.8%)	79 (36.2%)	85	60 (35.3%)	110 (64.7%)	<0.0001	3.2 (2.1–4.9)
Gotoh et al^Citation22	55	61 (55.5%)	49 (44.5%)	74	60 (40.5%)	88 (59.5%)	0.0058	2.0 (1.21–3.29)
Nakanishi et al^Citation17	375	418 (55.7%)	332 (44.3%)	847	627 (37.0%)	1067 (63.0%)	N/A	N/A
Fuse et al^Citation16	60	56 (46.7%)	64 (53.3%)	138	90 (32.6%)	186 (67.4%)	0.0077	1.80 (1.17–2.80)

Notes: P-values by Fisher’s exact test;

a indicates the risk alleles;

b the allele frequency was calculated from the reported genotype frequency.

Abbreviations: PCV, polypoidal choroidal vasculopathy; CI, confidence interval.

Table 3 The genotype distribution for each single nucleotide polymorphism in this study and other studies in Asians

	PCV			Controls			P-value
	CC	CT	TT	CC	CT	TT
Rs1061170 (Y402H)
Current study	3 (3.1%)	23 (23.7%)	71 (73.2%)	0 (0%)	11 (10.8%)	91 (89.2%)	0.002
Compiled studies	8 (0.7%)	227 (19.5%)	926 (79.8%)	14 (0.6%)	268 (11.7%)	2000 (87.6%)	<0.001
Gotoh et al^Citation19	2 (1.0%)	43 (21.1%)	159 (77.9%)	N/A	N/A	N/A	N/A
Lee et al^Citation20	0 (0%)	10 (13.9%)	62 (86.1%)	1 (1.1%)	8 (8.6%)	84 (90.3%)	N/A
Hayashi et al^Citation9	5 (1.0%)	96 (18.8%)	409 (80.2%)	8 (0.6%)	160 (11.9%)	1174 (87.5%)	N/A
Nakanishi et al^Citation17	1 (0.2%)	78 (20.8%)	296 (79.0%)	5 (0.6%)	100 (11.8%)	742 (87.6%)	3.4 × 10^−4
	GG	GA	AA	GG	GA	AA
Rs800292 (I62V)
Current study	46 (47.4%)	47 (48.5%)	4 (4.1%)	29 (28.5%)	59 (57.8%)	14 (13.7%)	0.005
Compiled studies	331 (56.8%)	209 (35.8%)	43 (7.4%)	492 (34.4%)	690 (48.2%)	249 (17.4%)	<0.001
Lee et al^Citation20	41 (56.9%)	27 (37.5%)	4 (5.6%)	36 (38.7%)	41 (44.1%)	16 (17.2%)	0.0175
Hayashi et al^Citation9	290 (56.8%)	182 (35.6%)	39 (7.6%)	456 (34.1%)	649 (48.5%)	233 (17.4%)	N/A
	TT	GT	GG	TT	GT	GG
Rs10490924 (A69S)
Current study	2 (33.0%)	1 (42.3%)	24 (24.7%)	13 (12.8%)	50 (49%)	39 (38.2%)	0.002
Compiled studies	270 (36.1%)	309 (41.4%)	168 (22.4%)	182 (13.7%)	616 (46.3%)	533 (40.0%)	<0.001
Kondo et al^Citation18	31 (40.8%)	33 (43.4%)	12 (15.8%)	15 (16.0%)	41 (43.6%)	38 (40.4%)	N/A
Lee et al^Citation20	25 (34.7%)	30 (41.7%)	17 (23.6%)	12 (12.9%)	48 (51.6%)	33 (35.5%)	0.0034
Sakurada et al^Citation21	45 (41.3%)	49 (44.9%)	15 (13.8%)	14 (16.5%)	32 (37.6%)	39 (45.9%)	<0.0001
Gotoh et al^Citation22	18 (32.7%)	25 (45.5%)	12 (21.8%)	12 (16.2%)	36 (48.6%)	26 (35.1%)	N/A
Nakanishi et al^Citation17	133 (35.5%)	152 (40.5%)	90 (24.0%)	113 (13.3%)	401 (47.3%)	333 (39.3%)	1.6 × 10^−14
Fuse et al^Citation16	18 (30.0%)	20 (33.3%)	22 (36.7%)	16 (11.6%)	58 (42.0%)	64 (46.4%)	0.0069

Note: P-value by Fisher’s exact test.

Abbreviation: PCV, polypoidal choroidal vasculopathy.

Table 4 The likelihood of homozygous or heterozygous risk genotype having PCV in this study and in the compiled data from other studies in Asians

Paired genotype		Current study		Compiled studies
		P-value	Odds ratio	P-value	Odds ratio
Rs1061170 (Y402H)	CC vs TT	0.839	8.96 (0.46–176.24)	0.649	1.234 (0.516–2.952)
	CT vs TT	0.006	2.974 (1.364–6.488)	<0.001	1.829 (1.508–2.219)
	CC vs CT	0.869	3.43 (0.16–72.04)	0.513	0.675 (0.278–1.637)
Rs800292 (I62V)	GG vs AA	0.005	5.5514 (1.665–18.513)	<0.001	3.896 (2.739–5.542)
	GA vs AA	0.087	2.7829 (0.861–9.031)	0.002	1.754 (1.225–2.511)
	GG vs GA	0.025	1.991 (1.090–3.636)	<0.001	2.221 (1.804–2.735)
Rs10490924 (A69S)	TT vs GG	0.001	4.0 (1.760–9.091)	<0.001	4.707 (3.645–6.078)
	TG vs GG	0.390	1.333 (0.692–2.565)	<0.001	1.591 (1.276–1.985)
	TT vs TG	0.005	3.002 (1.396–6.454)	<0.001	2.957 (2.344–3.731)

Notes: Logistic regression analysis was used to test the likelihood of homozygous or heterozygous risk genotype having PCV when paired with homozygous nonrisk genotype; odds ratios indicate significance at P < 0.0167 (0.05/3, Bonferroni correction); the homozygous risk genotypes are in bold; the studies included in the compiled data are listed in Table 3.

Abbreviations: PCV, polypoidal choroidal vasculopathy; vs, versus.

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