Association Between Anterior Chamber Angle and Corneal Endothelial Cell Density in Chronic Angle Closure

Figures & data

Table 1 Demographic Characteristics Across Different TIA Grading

	Grade 1 TIA (n = 16)	Grade 2 TIA (n = 24)	Grade 3 TIA (n = 12)	P value
Age (years)	64.56 ± 4.60	58.04 ± 8.44	54.25 ± 11.64	<0.01*
IOP (mmHg)	26.65 (21–48)	23.40 (21–66)	23.10 (21–45)	0.10**
Vertical CD ratio	0.75 ± 0.10	0.69 ± 0.17	0.67 ± 0.18	0.36*
Mean deviation	−16.25 ± 1.24	−4.43 (−32.27–2.17)	−8.24 (−33.63–0.35)	0.08**
Pattern standard deviation	3.42 (1.16–12.57)	3.18 (1.18–12.48)	4.57 ± 3.73	0.86**
RNFL thickness	75.56 ± 18.12	84.0 ± 25.06	75.83 ± 22.02	0.42*

Notes: *One-way ANOVA test; **Kruskal–Wallis test; significance is indicated with bold.

Abbreviations: CD, cup-to-disk; IOP, intraocular pressure; RNFL, retinal nerve fiber layer; TIA, trabecular iris angle.

Figure 1 Scatter plot of trabecular iris angle and presenting intraocular pressure (Spearman correlation r = −0.24; P = 0.09).

Figure 2 Scatter plot of trabecular iris angle and age (Spearman correlation r = −0.35; P = 0.01).

Table 2 Corneal Parameters Across Different TIA Grading

	Grade 1 TIA (n = 16)	Grade 2 TIA (n = 24)	Grade 3 TIA (n = 12)	P value
ECD (cells/mm^2)	2684.5 (1433–2934)	2587.0 (1902–3103)	2441.0 (1659–3005)	0.67*
CV (μm^2/cell)	38.3 ± 9.6	36.6 ± 6.6	36.4 ± 7.2	0.74*
Hexagonality (%)	51.6 ± 8.3	49.8 ± 11.9	52.4 ± 10.7	0.73*
CCT (microns)	538.6 ± 45.4	541.9 ± 29.9	551.9 ± 26.6	0.59**

Notes: *Kruskal–Wallis test; **one-way ANOVA test.

Abbreviations: CCT, central corneal thickness; CV, coefficient of variance; ECD, endothelial cell density; TIA, trabecular iris angle.

Table 3 Correlation of ECD, CV, Hexagonality, and CCT with Other Variables

Corneal Parameters	Age	Trabecular Iris Angle	Presenting IOP
ECD correlation	−0.06*	−0.13*	0.07*
Sig. (2-tailed)	0.67	0.35	0.61
CV correlation	−0.18**	−0.09*	0.01*
Sig. (2-tailed)	0.40	0.51	0.99
Hexagonality correlation	0.03**	−0.01*	<0.01*
Sig. (2-tailed)	0.86	0.93	0.98
CCT correlation	−0.19**	0.11*	<0.01*
Sig. (2-tailed)	0.18	0.46	0.98

Notes: *Spearman correlation; **pearson correlation; correlation is significant at 0.05 level (2-tailed).

Abbreviations: CCT, central corneal thickness; CV, coefficient of variance; ECD, endothelial cell density; IOP, intraocular pressure.