The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings

Figures & data

Table 1 Demographic Characteristics and Preoperative IOP, Schirmer, and TBUT Values of Patients Undergoing Primary Trabeculectomy with MMC

	Group 1 (n=19)	Group 2 (n=16)	p
Age (years, mean±SD)	56.50 ± 13.155	56.21 ± 12.49	0.95*
Sex female (n)	14	11	0.52**
Male (n)	5	5
IOP (mmHg, mean±SD)	29.44 ± 7.89	30.79 ± 9.91	0.66*
Schirmer (mm, mean±SD)	9.69 ± 4.53	9.05 ± 4.71	0.69*
TBUT (second, mean±SD)	4.81 ± 2.40	5.84 ± 2.73	0.25*

Abbreviations: IOP, intraocular pressure; TBUT, tear break up time; p*, independent t test; p**, chi square test.

Table 2 Postoperative Bleb Morphology of Patients Undergoing Primary Trabeculectomy with MMC According to Indiana Bleb Grading System⁵ (Bleb Height, Horizontal Extent, Vascularization and Bleb Leakage in Seidel Test)

	Group 1 (n=19)	Group 2 (n=16)	p
1st day bleb height	1.25 ± 0.68	1.05 ± 0.23	0.24
1st day horizontal extent	1.94 ± 0.68	1.47 ± 0.51	0.03
1st day bleb vascularization	2.25 ± 0.45	2.11 ± 0.46	0.35
1st week bleb height	1.57 ± 0.65	1.37 ± 0.49	0.31
1st week horizontal extent	2.07 ± 0.62	1.53 ± 0.61	0.02
1st week bleb vascularization	2.00 ± 0.11	2.21 ± 0.71	0.28
2nd week bleb height	1.53 ± 0.52	1.18 ± 0.41	0.07
2nd week horizontal extent	2.13 ± 0.51	2.00 ± 0.45	0.49
2nd week bleb vascularization	1.00 ± 0.65	2.09 ± 0.83	0.001
1st month bleb height	1.53 ± 0.64	1.11 ± 0.32	0.02
1st month horizontal extent	2.20 ± 0.41	1.83 ± 0.51	0.03
1st month bleb vascularization	0.93 ± 0.59	1.11± 0.96	0.53
2nd month bleb Height	2.20 ± 2.21	1.35 ± 0.49	0.13
2nd month horizontal extent	2.20 ± 0.41	1.82 ± 0.53	0.03
2nd month bleb vascularization	0.80 ± 0.56	1.19 ± 0.77	0.050

Notes: P: independent sample t test, values less than 0.05 were considered significant and shown as bold. The Seidel test was not observed postoperatively at all visits.

Table 3 Postoperative IOP

Group (n:Number)	Group 1 (n:19)	Group 2 (n:16)	p
1st day IOP (mmHg, mean±SD)	11.56 ± 6.48	11.79 ± 4.50	0. 90
1st week IOP (mmHg, mean±SD)	10.53 ± 3.54	12.16 ± 2.11	0.11
2nd week IOP (mmHg, mean±SD)	10.86 ± 3.25	12.31 ± 2.09	0.16
1st month IOP (mmHg, mean±SD)	12.50 ± 3.21	12.22 ± 1.86	0.76
2nd month IOP (mmHg, mean±SD)	12.29 ± 4.19	12.41 ± 1.91	0. 91

Abbreviations: IOP, intraocular pressure; P, independent sample t test.

Table 4 Postoperative Schirmer Values

	Group 1 (n=19)	Group 2 (n=16)	p
1st day schirmer (mm, mean±SD)	18.75 ± 6.39	16.00 ± 6.28	0.21
1st week schirmer (mm, mean±SD)	12.20 ± 6.48	10.26 ± 4.99	0.33
2nd week schirmer (mm, mean±SD)	12.00 ± 5.49	8.81 ± 3.83	0.06
1st month schirmer (mm, mean±SD)	11.56 ± 6.07	9.28 ± 3.89	0.18
2nd month Schirmer (mm, mean±SD)	11.44 ± 5.18	9.35 ± 1.73	0.12

Note: P: independent sample t test.

Table 5 Postoperative TBUT Values

	Group 1 (n=19)	Group 2 (n=16)	p
1st day TBUT (second, mean±SD)	5.56 ± 1.63	6.63 ± 2.43	0.14
1st week TBUT (second, mean±SD)	5.33 ± 1.11	6.11 ± 2.26	0.24
2nd week TBUT (second, mean±SD)	5.06 ± 1.29	4.94 ± 2.08	0.84
1st month TBUT (second, mean±SD)	5.19 ± 1.17	5.56 ± 1.50	0.08
2nd month TBUT (second, mean±SD)	5.69 ± 1.09	6.47 ± 2.43	0.24

Abbreviations: TBUT, tear break up time; P, independent sample t test.

Cantor LB, Mantravadi A, WuDunn D, Swamynathan K, Cortes A. Morphologic classification of filtering blebs after glaucoma filtration surgery: the Indiana bleb appearance grading scale. J Glaucoma. 2003;12:266–271. doi:10.1097/00061198-200306000-00015

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