The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma

Figures & data

Figure 1 Overview of study design.

Table 1 Characteristics of Normal Tension Glaucoma Patients

Demographics	All	8-OHdG < 6.86 (ng/mg Creatinine)	8-OHdG > 6.86 (ng/mg Creatinine)	P-value
Number of patients	30	19	11	–
Age (years)	59.1± 9.0	60.7 ± 8.5	56.3 ± 9.6	0.23
Sex (male: female)	15: 15	10: 9	5: 6	1.00*
Visual acuity (logMAR)	0.11 ± 0.37	0.01 ± 0.30	0.08 ± 0.34	0.28
IOP (mmHg)	11.03 ± 2.25	11.48 ± 1.87	11.58 ± 1.97	0.94
Mean deviation (dB)	−14.24 ± 6.58	−15.20 ± 6.36	−12.89 ± 6.99	0.49
BMI (kg/m^2)	22.34 ± 2.15	23.14 ±1.59	20.95 ± 2.35	0.02
8-OHdG (ng/mg creatinine)	6.86 ± 3.52	4.69 ± 1.41	10.59 ± 2.88	< 0.01
BAP (μmol/L)	2022.37 ± 139.94	2039.56 ± 110.53	1992.64 ± 182.40	0.64
Diabetes (%)	1 (3.33)	0 (0.00)	1 (9.09)	0.37*
Hypertension (%)	4 (13.33)	4 (21.05)	0 (0.00)	0.27*
Current smoker (%)	6 (20.00)	3 (15.79)	3 (27.27)	0.64*
Hyperlipidemia (%)	6 (20.00)	5 (26.32)	1 (9.09)	0.37*

Notes: Unmarked P values: Mann–Whitney U-test; *Fisher exact test.

Abbreviations: 8-OHdG, 8-hydroxy-2ʹ-deoxyguanosine; logMAR, logarithm of minimum angle of resolution; IOP, intraocular pressure; BMI, body mass index; BAP, biological antioxidant potential.

Figure 2 Comparison of findings before and after antioxidant treatment in patients with glaucoma. (A) There was no significant increase in 8-OHdG level. (B) BAP level significantly increased at weeks 8 and 16. *p < 0.05.

Figure 3 Comparison of findings before and after antioxidant treatment in patients with relatively high or low oxidative stress. (A) There was a significant increase in the 8-OHdG level at weeks 12 and 16 in patients with relatively low oxidative stress. (B) There was a significant decrease in 8-OHdG level at weeks 4, 8, 12 and 16 in patients with relatively high oxidative stress. (C) BAP level did not significantly change before and after treatment in patients with relatively low oxidative stress. (D) BAP level significantly increased at weeks 8 and 12 in patients with relatively high oxidative stress. *p < 0.05, **p < 0.01, ***p < 0.001.