Choroidal Blood Flow After Intravitreal Ranibizumab in Vitrectomized and Non-Vitrectomized Eyes with Diabetic Macular Edema

Figures & data

Table 1 Baseline Characteristics

Parameter	Group 1 (n=10)	Group 2 (n=24)	p-value
Age, mean [95% CI]	66.5 [60.2–72.8]	68.4 [65.1–71.7]	0.467
Gender female, n (%)	5 (50.0)	14 (58.3)	0.718
DM duration (years), mean [95% CI]	22.1 [16.5–27.7]	15.7 [12.4–19.0]	0.020
DME duration (months), mean [95% CI]	34.0 [7.8–60.2]	23.0 [13.7–32.4]	0.619
Type 2 DM, n (%)	10 (100.0)	24 (100.0)	1.000
Macular LASER, n (%)	8 (80.0)	15 (62.5)	0.437
PRP LASER, n (%)	8 (80.0)	13 (54.2)	0.251
Naive IV, n (%)	2 (20.0)	6 (25.0)	1.000
HbA1c, mean [95% CI]	7.6 [6.8–8.3]	7.3 [6.9–7.7]	0.589
Hemoglobin, mean [95% CI]	13.1 [11.8–14.4]	13.1 [12.3–13.9]	0.985
Microproteinuria, mean [95% CI]	112.7 [19.8–245.3]	181.1 [51.7–310.6]	0.908
BMI, mean [95% CI]	28.0 [25.1–30.9]	27.8 [26.3–29.3]	0.724
SBP, mean [95% CI]	138.5 [127.1–149.9]	138.4 [133.1–143.7]	0.832
DBP, mean [95% CI]	74.3 [65.6–83.0]	77.1 [73.6–80.6]	0.406
BCVA (letters), mean [95% CI]	63.3 [52.5–74.7]	72.3 [52.5–74.7]	0.196
CFT (μm), mean [95% CI]	400.5 [343.1–457.9]	433.7 [390.7–476.7]	0.381
CVI, mean [95% CI]	0.633 [0.603–0.662]	0.641[0.611–0.671]	0.324
CCD (%), mean [95% CI]	0.392 [0.337–0.448]	0.373 [0.319–0.428]	0.764
CT, mean [95% CI]	233.7 [172.1–295.3]	256.1 [232.1–280.1]	0.349

Note: Significant P-value in bold.

Abbreviations: Group 1, vitrectomized eyes; Group 2, non-vitrectomized eyes; 95% CI, 95% confidence interval; DM, diabetes mellitus; DME, diabetic macular edema; macular LASER, prior focal-grid photocoagulation treatment in the study eye; PRP LASER, Prior panretinal photocoagulation treatment in the study eye; IV, intravitreal; naïve IV, no prior anti-VEGF intravitreal treatment in study eye; CCT, corticosteroid; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; CVI, choroidal vascularity index; CCD, choriocapillaris flow density, CT, choroidal thickness.

Figure 1 Change in BCVA from baseline to 6 months of follow-up.

Figure 2 Change in CFT from baseline to 6 months of follow-up.

Table 2 Changes in CVI, CCD, and CT, Globally and by Group

	Group 1 [n=10]	Group 2 (n=24)	Total (n=34)
CT, μm	233.7 ± 73.7	256.1 ± 52.7	250.0 ± 58.7	Baseline
	272.6 ± 87.1	245.5 ± 55.9	254.2 ± 67.3	6-months
	+38.9, p=0.109	−10.6, p=0.042	+4.2, p=0.508	Change, p-value
CVI, %	63.3 ± 3.5	64.1 ± 6.5	63.9 ± 5.8	Baseline
	63.5 ± 6.1	66.2 ± 5.6	65.3 ± 5.8	6-months
	+0.2, p=0.945	+2.1, p=0.111	+1.4, p=0.169	Change, p-value
CCD, %	39.3 ± 7.2	37.3 ± 11.6	37.9 ± 10.4	Baseline
	39.3 ± 11.3	41.2 ± 10.9	40.6 ± 10.9	6-months
	0.0, p=0.109	+3.9, p=0.042	+3.7, p=0.100	Change, p-value

Notes: Significant P-values in bold. Values are shown as mean±standard deviation. P-values from Wilcoxon tests.

Abbreviations: group 1, vitrectomized eyes; group 2, non-vitrectomized eyes; BCVA, best-corrected visual acuity; CFT, central foveal thickness; CT, choroidal thickness; CVI, choroidal vascularity index; CCD, choriocapillaris flow density.