Twenty-Four-Hour Intraocular Pressure Control with Omidenepag Isopropyl 0.002% in Patients with Glaucoma and Ocular Hypertension

Figures & data

Table 1 Demographic Characteristics of Study Paticipants

Gender	20 male, 5 female
Age (years)	52.2 ± 8.5 (40–73)
Diagnosis	18 POAG, 7 OH
Central cornea thickness (μm)	545.2 ± 42.2 (454–623)
Systolic blood pressure (mmHg)	121.2 ± 13.7 (95–144)
Diastolic blood pressure (mmHg)	77.1 ± 10.0 (55–99)
Heart rate (beats/min)	70.6 ± 8.4 (53–89)

Notes: Value represents the mean ± standard deviation (range). Blood pressure and heart rate data show average for 24 hours in sitting position.

Abbreviations: POAG, primary open angle glaucoma; OH, ocular hypertension.

Figure 1 Effect of omidenepag isopropyl on 24-hour IOP (sitting position, Goldmann applanation tonometer). Sitting IOP measurements were taken from 25 patients during 24-hour period. The baseline is indicated by open circles, and omidenepag isopropyl 0.002% treatment for 4 weeks by closed circles. Values are presented as the mean ± standard deviation. *P< 0.01 vs the baseline by paired t-test.

Abbreviation: IOP, intraocular pressure.

Figure 2 Effect of omidenepag isopropyl on 24-hour IOP (habitual position, Icare PRO tonometer). IOP measurements were taken from 25 patients habitual position (sitting during the diurnal period and supine during the nocturnal period). Data were from the same subjects as in Figure 1. The baseline is indicated by open circles, and omidenepag isopropyl 0.002% treatment for 4 weeks by closed circles. Values are presented as the mean ± standard deviation. *P<0.05 vs baseline by paired t-test.

Abbreviation: IOP, intraocular pressure.

Table 2 Mean IOP Before and After Treatment with Omidenepag Isopropyl 0.002%

	Baseline (mmHg)	Treatment (mmHg)	Difference (mmHg)	p value
Sitting IOP (GAT)
Diurnal Mean IOP	19.1 ± 2.1	16.3 ± 2.4	−2.8 ± 2.6	<0.0001
Nocturnal Mean IOP	18.2 ± 2.6	14.8 ± 2.6	−3.3 ± 2.9	<0.0001
24-hour Mean IOP	18.7 ± 2.2	15.6 ± 2.4	−3.1 ± 2.5	<0.0001
Habitual IOP (Icare PRO)
Diurnal Mean IOP (sitting)	17.21 ± 1.67	16.08 ± 1.44	−1.12 ± 1.49	0.0010
Nocturnal Mean IOP (supine)	17.99 ± 2.22	16.20 ± 2.27	−1.78 ± 2.37	0.0009

Notes: All data represent the mean ± standard deviation (N=25). Diurnal points: 9 am, 1 pm, and 5 pm. Nocturnal points: 9 pm, 1 am, and 5 am. Habitual IOP: sitting during the diurnal period and supine during the nocturnal period. P value performed with paired t-test.

Abbreviations: GAT, Goldmann applanation tonometer; Icare PRO, Icare PRO tonometer; IOP, intraocular pressure.

Table 3 Mean OPP Before and After Treatment with Omidenepag Isopropyl 0.002%

	Baseline (mmHg)	Treatment (mmHg)	Difference (mmHg)	p value
Diurnal Mean OPP	41.7 ± 7.6	44.8 ± 7.7	3.0 ± 4.7	0.0032
Nocturnal Mean OPP	43.4 ± 7.3	47.1 ± 6.6	3.7 ± 4.0	0.0001
24-hour Mean OPP	42.6 ± 7.2	45.9 ± 7.0	3.4 ± 3.9	0.0002

Notes: Each value represents the mean ± standard deviation. Diurnal points: 9 am, 1 pm, and 5 pm. Nocturnal points: 9 pm, 1 am, and 5 am. P value performed with paired t-test.

Abbreviation: OPP, ocular perfusion pressure.