Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension

Figures & data

Table 1 Demographic features of study groups

n		Female n (%)	Male n (%)	Age*
TBD	56	42 (76)	14 (24)	62.5 ± 10.2
TB	56	56 44 (80)	12 (20)	60.6 ± 12.7

Note:

* Data is presented in mean ± standard deviation.

Abbreivations: TBD, timolol-brimonidine-dorzolamide; TB, timololbrimonidine.

Figure 1 Mean change from baseline IOP at each visit between groups at 8 am.

Abbreviations: IOP, Intra Ocular Pressure; TBD, timolol-brimonidine-dorzolamide; TB, timolol-brimonidine.

Figure 2 Mean change from baseline IOP at each visit between treatment groups at 4 pm.

Abbreviations: IOP, Intra Ocular Pressure; TBD, timolol-brimonidine-dorzolamide; TB, timolol-brimonidine.

Table 2 Difference in IOP between groups at 8 am

	TBD (n = 108)	TB (n = 104)	P
Baseline	22.3 ± 0.9	22.4 ± 1.8	0.558
Day 15	18.0 ± 2.0	19.5 ± 3.4	0.000
Day 30	16.4 ± 1.5	18.4 ± 1.3	0.000
Day 60	16.3 ± 2.5	18.3 ± 2.0	0.000
Day 90	16.2 ± 2.0	18.4 ± 1.4	0.000

Note: Data is presented in mean ± standard deviation.

Abbreviations: IOP, Intra Ocular Pressure; TBD, timolol-brimonidine-dorzolamide; TB, timololbrimonidine.

Table 3 Difference in IOP between groups at 4 pm

	TBD (n = 108)	TB (n = 104)	P
Baseline	19.0 ± 1.3	19.1 ± 1.2	0.536
Day 15	15.4 ± 1.2	17.8 ± 0.9	0.000
Day 30	15.3 ± 1.3	17.5 ± 1.7	0.000
Day 60	15.0 ± 2.3	17.0 ± 2.6	0.000
Day 90	14.7 ± 2.4	16.8 ± 1.4	0.000

Note: Data is presented in mean ± standard deviation.

Abbreviations: IOP, Intra Ocular Pressure; TBD, timolol-brimonidine-dorzolamide; TB, timololbrimonidine.

Table 4 Adverse events presented in study groups

	TBD (n = 56)	TB (n = 56)
Ocular burning	1b	1a
Itching	1c
Foreign body sensation	1a
Redness		1c
Dizziness		1c
Cephalea		1a
Bradycardia		1a

Note: Classified as:

a Mild;

b moderate;

c severe.

Abbreivations: TBD, timolol-brimonidine-dorzolamide; TB, timolol-brimonidine.