Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes

Figures & data

Table 1 Baseline Patient and Clinical Characterises Prior to Siluron2000 Insertion

Patient and Clinical Characteristics	n/Mean	%/SD
Mean age, years	63.1	13.1
Female	20	35
Prior retinal surgery	43	75
SB	13	23
PPV	23	40
SB/PPV	7	12
No previous surgery	14	24
Initial Diagnosis
RRD	33	58
PVR-RD	5	9
GT-RD	6	10
FTMH	6	10
TRD	7	12
Pre-Siluron2000 Diagnosis
FTMH	6	11
PVR	51	89

Abbreviations: SB, scleral buckle; PPV, pars plana vitrectomy; RRD, rhegmatogenous retinal detachment; PVR-RD, proliferative vitreoretinopathy – retinal detachment; GT-RD, giant-tear with retinal detachment; FTMH, full-thickness macular hole; TRD, tractional retinal detachment; PVR, proliferative vitreoretinopathy.

Table 2 Summary of Primary Outcomes and Long-Term Complications Following Siluron2000 Insertion

Variable	n/Median	%/IQR
Follow-up duration, months	18	15–22
Duration with intact Siluron2000, months	17	12–21
Anatomical Outcomes
Proliferative vitreoretinopathy (n=51)
Retinal reattachment	47	82
Recurrent detachment under oil	10	17
Inferior RD	6	10
Total RD	4	7
Full thickness macular hole (n=6)
Macular hole closure	5	83
Visual acuity at last follow-up, logMAR	1.6	1.2–1.7
Time to Siluron2000 removal
≤ 6 months	6	11
> 6 months	3	5
Complications
Silicone oil emulsification	9	16
Corneal haze	1	2
Epiretinal membrane	2	4
Cystoid macular edema	1	2
Cataract	11	19
Elevated intraocular pressure (IOP, >20)	4	7
Patient requiring glaucoma drops to control IOP	12	21

Abbreviations: RD, retinal detachment; logMAR, logarithm of the minimum angle of resolution.

Table 3 Linear Regression Analysis of the Association of Visual Acuity at Last Follow-Up with Other Variables in Eyes with Siluron2000 Insertion

Variable*	Beta (Standardized Coefficients)	95% CI	p value**
Visual acuity at baseline, logMAR	−0.004	−0.22–0.021	0.977
Duration of intact Siluron2000 in the vitreous cavity	0.162	−0.105–0.42	0.233

Notes: Results are reported from general linear regression model. **All variables used in the linear regression model are continuous variables, including the visual acuity at last follow-up. A larger logMAR is suggestive of worse vision. *Statistically significant (p < 0.05).

Abbreviation: logMAR, logarithm of the minimum angle of resolution.