Factors Affecting Final Surgical Outcome of Combined Trabeculotomy–Trabeculectomy in Primary Congenital Glaucoma

Figures & data

Table 1 Pre-operative Patient’s Data

Variable	(Mean± SD)/No (%)
Sex
-Male patients	● 24 (66.7%)
-Female patients	● 12 (33.3%)
Patients’ Age	6.18 ± 2.8 months Range (1.5–11 months)
Family history
-Positive patients	● 9 (25%)
-Negative patients	● 27 (75%)
Consanguinity
-Positive patients	● 13 (36.1%)
-Negative patients	● 23 (63.9%)
IOP	27.65 ± 2.6 mmHg Range (23–34 mmHg)
Corneal diameter	13 ± 0.56 mm Range (12–14 mm)
Corneal edema
-Superficial epithelial edema	● 22 (34.9%)
-Central edema involving both epithelium and parenchyma	● 32 (50.8%)
-Total diffuse edema obscuring fundus details	● 9 (14.3%)

Table 2 Probability Outcome of CTT Surgery in PCG Using Kaplan–Meier Survival Analysis, with Univariate Analysis Comparing Final Surgical Outcome According to Pre-Operative Variables

Total Number of Eyes According to Pre-Operative Variable (%)	Number of Failures	Probability of Failure	Probability of Success at 95% CI	Log Rank Test	Mean Survival Time (Days)	P value
Between groups
-CTT = 21 (33.3%)	● 3	● 0.143	● 0.86	0.252	● 318.6 (269.9–367.3)	0.882
-CTTM = 21 (33.3%)	● 2	● 0.095	● 0.90		● 333 (291.04–375.2)
-CTTO = 21 (33.3%)	● 3	● 0.143	● 0.86		● 320 (272.8–367.2)
Age at surgery
-< 6 months = 26 (41.3%)	● 4	● 0.154	● 0.85	0.351	● 313.46 (267–359.9)	0.553
-≥ 6 months = 37 (58.7%)	● 4	● 0.108	● 0.89		● 331.22 (299.9–362.5)
Sex
-Male = 42 (66.7%)	● 7	● 0.167	● 0.83	1.8	● 310.6 (273.8–347.4)	0.180
-Female = 21 (33.3%)	● 1	● 0.048	● 0.95		● 350.5 (322.7–378.3)
Family history
-Positive = 15 (23.8%)	● 2	● 0.133	● 0.87	0.014	● 320.3 (262.7–377.9)	0.906
-Negative = 48 (76.2%)	● 6	● 0.125	● 0.88		● 325 (295–354.9)
Consanguinity
-Positive = 22 (34.9%)	● 4	● 0.182	●0.82	0.95	● 305.5 (252.6–358.3)	0.330
-Negative = 41 (65.1%)	● 4	● 0.098	●0.90		● 333.8 (304.7–362.9)
IOP
-<30 mmHg = 42 (66.7%)	● 2	● 0.048	● 0.95	7.28	● 349.8 (329.1–370.1)	0.007
-≥30 mmHg = 21 (33.3)	● 6	● 0.286	● 0.71		● 272.1 (209.3–335)
Corneal diameter
-<13 mm = 25 (39.7%)	● 3	● 0.12	● 0.88	0.017	● 326 (284.6–367.4)	0.897
-≥13 mm = 38 (60.3%)	● 5	● 0.13	● 0.87		● 322.5 (287.7–357.3)
Corneal clarity
-SE = 22 (34.9%)	● 4	● 0.182	● 0.82	2.68	● 305.5 (252.6–358.3)	0.262
-CE = 32 (50.8%)	● 2	● 0.063	● 0.94		● 345.9 (320.4–371.5)
-TE = 9 (14.3%)	● 2	● 0.22	● 0.78		● 290.6 (199.6–381.5)

Abbreviations: CI, confidence interval; IOP, intraocular pressure; CTT, combined trabeculotomy–trabeculectomy; CTTM, combined trabeculotomy–trabeculectomy augmented with mitomycin-C; CTTO, combined trabeculotomy–trabeculectomy augmented with Ologen; SE, superficial epithelial edema; CE, central edema involving both epithelium and parenchyma; TE, total diffuse edema obscuring fundus details.

Figure 1 Kaplan-Meier curve showing the success probabilities in relation to pre-operative IOP.