Chromatic Full-Field Stimulus Thresholds in Patients with Treatment-Naive Age-Related Macular Degeneration

Figures & data

Figure 1 Visit schedule with ophthalmological examinations and intravitreal injections at all visits.

Abbreviations: VA, visual acuity; FP, fundus photography; FA, fluorescein angiography; FCt, foveal optical coherence tomography thickness; FST, full-stimulus threshold; IVI, intravitreal injection.

Table 1 General Demographics and Results of All Patients at Baseline

Demographics and Results	e-ARMD	Normal Subjects
	N or Mean ± SD
Age (years)	73.2 ± 14.0	44.68 ± 18.3
Gender
Male	8	8
Female	12	11
Baseline VA	0.44 ± 0.27	0.87 ± 0.24
Baseline FCt	323.9 ± 186.9 µm	281.6 ± 31.7 µm
Baseline Blue FST	−31.9 ± 10.4 dB	−54.28 ± 12.0 dB
Baseline Green FST	−25.8 ± 9.0 dB	−45.56 ± 2.55 dB
Baseline Red FST	−14.4 ± 8.1 dB	−28.52 ± 7.95 dB

Abbreviations: e-ARMD, exudative age-related macular degeneration; N, number; SD, standard deviation; VA, visual acuity; FCt, foveal optical coherence tomography thickness; FST, full-stimulus threshold.

Table 2 Results of All Patients in the e-ARMD Group Before the 1st, After the 2nd and the 3rd Intravitreal Injection

	1st Intravitreal Injection (Mean ± SD)	2nd Intravitreal Injection (Mean ± SD)	3rd Intravitreal Injection (Mean ± SD)
VA (decimal number)	0.50 ± 0.25	0.51 ± 0.28	0.51 ± 0.27
FCt (µm)	291.4 ± 131.0	273.6 ± 108.0	262.7 ± 99.7
Blue FST (dB)	−33.7 ± 7.8	−33.5 ± 7.6	−31.8 ± 7.8
Green FST (dB)	−29.6 ± 11.1	−26.8 ± 7.6	−25.1 ± 9.8
Red FST (dB)	−15.0 ± 4.9	−6.0 ± 30.0	−13.9 ± 4.9

Abbreviations: SD, standard deviation; VA, visual acuity; FCt, foveal optical coherence tomography thickness; FST, full-stimulus threshold.

Figure 2 Correlation analysis of foveal central thickness (FCt) with parameters of the chromatic FST (blue, green and red FST). A moderate significant correlation between the blue FST and the FCt after the 2nd intravitreal treatment is shown in (A) (p = 0.04, r = 0.44 of Pearson's correlation coefficient test). After the 3rd intraviral treatment, a highly significant correlation between the blue FST and the FCt is shown in (B) (p = 0.0007, r = 0.67). For the green and red FST a similar high correlation is show after the 3rd intravitreal treatment in (C) (green: p = 0.003, r = 0.61) and (D) (red: p = 0.01, r = 0.54).

Abbreviations: FCt, foveal optical coherence tomography thickness; FST, full-stimulus threshold; r, Pearson’s correlation coefficient.