Pachymetric Assessment After EpiSmart^® Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia

Figures & data

Table 1 Baseline Pachymetry and Changes from Baseline to Follow-Up Time Points. Means, Minimum, Maximum, Standard Deviation (SD), and Standard Error of the Mean (SE) are Expressed in Microns. The 95% Confidence Interval is Given for the Pachymetry Results Where Distributions Appeared Normal (at Month 6 and Month 12 Post-Op)

(Microns)	Baseline	Month 3	Month 6	Month 12
Count	101	97	90	75
Mean	451.4	−1.19	0.51	0.36
SD	49.6	14.71	15.40	14.11
Maximum	549	52	45	45
Minimum	277	−37	−42	−36
SE		1.49	1.62	1.63
Change: p-value (t-test vs baseline)		0.419	0.739	0.798
Normality: p-value (Shapiro–Wilk test)		<0.001	0.261	0.501
95% CI (assumes normality)			(−2.7, 3.7)	(−2.8, 3.5)

Figure 1 The means of pachymetry changes from baseline do not vary significantly from zero (p > 0.4).

Figure 2 Histograms of post-operative pachymetry changes are superimposed. Blue, red, and green bars show the distribution of changes from baseline to the 3-, 6-, and 12-month post-op follow up time points.

Figure 3 Distributions of change from baseline to 3 months (top), 6 months (middle) and 12 months (bottom) post-op. Q-Q plots (at right) for each distribution show quantiles vs that of a Gaussian distribution of best fit. Only the 3-month post-op distribution departs from normalcy. The 6- and 12-month post-op distributions appear approximately normal.