Comparison of the Accuracy of Intraoperative Aberrometry in Intraocular Lens Implantation Between Myopic Eyes with Emmetropia and Myopia Targets

Figures & data

Table 1 Characteristics of the Patients and Implanted Intraocular Lenses

	Target		P value
	Emmetropia (n = 39)	Intentional Myopia (n = 22)
Age (years), mean ± SD	64.7 ± 8.6	70.7 ± 11.1	0.027*
Female, n (%)	24 (61.5%)	10 (45.5%)	0.225
Axial length (mm)
Mean ± SD	26.8 ± 1.5	26.7 ± 1.4	0.881
Median (IQR)	26.4 (2.1)	26.4 (2.1)
Range	25.1–31.3	25.2–30.9
Average keratometry (mm)
Mean ± SD	7.78 ± 0.43	7.64 ± 0.26	0.235
Median (IQR)	7.71 (0.44)	7.61 (0.32)
Range	7.01–9.65	7.12–8.14
White to white (mm)
Mean ± SD	12.0 ± 0.4	11.9 ± 0.4	0.249
Median (IQR)	12.0 (0.6)	11.9 (0.6)
Range	11.2–12.9	11.2–12.7
IOL power (D)
Mean ± SD	11.4 ± 3.7	16.2 ± 3.6	<0.001*
Median (IQR)	11.0 (5.0)	16.8 (3.9)
Range	1.0–21.0	7.5–21.0
Postoperative refraction (spherical equivalent, D)
Mean ± SD	0.003 ± 0.42	−3.65 ± 0.85	<0.001*
Median (IQR)	0 (0.38)	−3.44 (1.16)
Range	−1.00 to 1.25	−5.88 to −2.50

Notes: *Significant at P < 0.05 (Mann–Whitney U-test).

Abbreviations: IOL, intraocular lens; SD, standard deviation; IQR, interquartile range.

Table 2 Prediction Error of Intraoperative Aberrometry

	Target		P value
	Emmetropia (n = 39)	Intentional Myopia (n = 22)
Numerical error (D)
Mean ± SD	0.04 ± 0.39	−0.37 ± 0.54^†	0.001*
Median (IQR)	0.06 (0.39)	−0.38 (0.60)
Range	−1.11 to 1.00	−1.50 to 0.79
Hyperopic error, n (%)	21 (53.8%)	5 (22.7%)
Myopic error, n (%)	18 (46.2%)	17 (77.3%)
Absolute error (D)
Mean ± SD	0.28 ± 0.27	0.51 ± 0.41	0.014*
Median (IQR)	0.18 (0.37)	0.40 (0.46)
Range	0.01–1.11	0.04–1.50
±0.25 D, n (%)	21 (53.8%)	8 (36.4%)
±0.50 D, n (%)	33 (84.6%)	14 (63.6%)
±0.75 D, n (%)	37 (94.9%)	17 (77.3%)
±1.00 D, n (%)	38 (97.4%)	19 (86.4%)

Notes: *Significant at P < 0.05 (Mann–Whitney U-test). ^†Significantly different from zero at P < 0.05 (one-sample t-test).

Abbreviations: SD, standard deviation; IQR, interquartile range.

Figure 1 Box and whisker plots of the numerical (A) and absolute (B) errors of intraoperative aberrometry in eyes with target of emmetropia and intentional myopia. The horizontal line in the box represents the median. The top and bottom of the box represent the upper and lower quartiles respectively. The whisker above the box represents the values within 1.5 times the of interquartile range plus the upper quartile. The whisker below the box represents the values within 1.5 times of the interquartile range minus the lower quartile. Values, which are not included between whiskers were plotted as outliers.

Table 3 Comparison Between Accuracy of Intraoperative Aberrometry and Intraocular Lens Calculation Formulas in 39 Eyes with Target of Emmetropia

	IA	SRK/T	Holladay 1	Hoffer Q	Holladay 2	Haigis	Barrett Universal II
Absolute error (n = 39)
Mean ± SD	0.28 ± 0.27	0.38 ± 0.36	0.59 ± 0.40	0.56 ± 0.39	0.47 ± 0.37	0.44 ± 0.35	0.35 ± 0.33
Median (IQR)	0.18 (0.37)	0.26 (0.46)	0.58 (0.57)	0.47 (0.61)	0.36 (0.44)	0.37 (0.42)	0.27 (0.29)
Range	0.01–1.11	0.01–1.64	0.02–1.84	0.01–1.66	0.03–1.69	0.02–1.47	0.01–1.46
P value (vs IA)		0.121	<0.001*	<0.001*	0.015*	0.311	0.513

Notes: The mean absolute errors varied significantly between the 7 groups (P < 0.001, Friedman test). *Significant at P < 0.05 vs intraoperative aberrometry (Wilcoxon signed-rank test with Bonferroni correction).

Abbreviations: IA, intraoperative aberrometry; SD, standard deviation; SRK/T, Sanders, Retzlaff, and Kraft/theoretical.

Table 4 Comparison Between Accuracy of Intraoperative Aberrometry and Intraocular Lens Calculation Formulas in 22 Eyes with Target of Intentional Myopia

	IA	SRK/T	Holladay 1	Hoffer Q	Holladay 2	Haigis	Barrett Universal II
Absolute error (n = 22*)
Mean ± SD	0.51 ± 0.41	0.52 ± 0.38	0.67 ± 0.52	0.57 ± 0.40	0.47 ± 0.35	0.50 ± 0.40	0.39 ± 0.38
Median (IQR)	0.40 (0.46)	0.43 (0.59)	0.51 (0.74)	0.48 (0.62)	0.36 (0.44)	0.45 (0.50)	0.26 (0.43)
Range	0.04–1.50	0.03–1.36	0.03–1.94	0.09–1.59	0.03–1.69	0.06–1.40	0.01–1.40

Notes: The mean absolute errors were not significantly different between the 7 groups (P = 0.051, Friedman test). *Holladay 2: n = 21.

Abbreviations: IA, intraoperative aberrometry; SD, standard deviation; SRK/T, Sanders, Retzlaff, and Kraft/theoretical.