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Clinical Ophthalmology Volume 16, 2022 - Issue
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Review

Ocular Gene Therapy: A Literature Review with Special Focus on Immune and Inflammatory Responses

Hashem H GhorabaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Amir AkhavanrezayatSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Irmak KaracaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAORCID Iconhttps://orcid.org/0000-0001-7927-0887View further author information
ORCID Icon,
Negin YavariSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Sherin LajevardiSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Jaclyn HwangSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAORCID Iconhttps://orcid.org/0000-0001-7756-3918View further author information
ORCID Icon,
Jonathan RegenoldSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Wataru MatsumiyaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Brandon PhamSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Moosa ZaidiSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Azadeh MobasserianSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Anthony Toan DongChauSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Christopher OrSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Cigdem YasarSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAORCID Iconhttps://orcid.org/0000-0003-0386-3613View further author information
ORCID Icon,
Kapil MishraSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
,
Diana DoSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USAView further author information
&
Quan Dong NguyenSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USACorrespondence[email protected]
View further author information
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Pages 1753-1771 | Published online: 03 Jun 2022

Figures & data

Table 1 Ocular Gene Therapy Clinical Trials*

Figure 1 Images showing different methods of intraocular gene delivery: (A) intravitreal, (B) suprachoroidal, and (C) subretinal.

Figure 1 Images showing different methods of intraocular gene delivery: (A) intravitreal, (B) suprachoroidal, and (C) subretinal.

Table 2 Key Differences Between Different Types of Modes of Delivery of Gene Therapy

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