Quantitative OCT Angiography Assessment of the Effect of Peribulbar Anesthesia on Retinal Microvasculature in Primary Open-Angle Glaucoma Patients Undergoing Cataract Surgery

Figures & data

Table 1 General Characteristics of the Studied Groups

		Group I (n = 26)	Group II (n = 23)	P-value
Age (years)	Mean ±SD	58 ±6	56 ±7	0.258
Sex	Males n (%)	16 (61.5)	12 (52.2)	0.509
	Females n (%)	10 (38.5)	11 (47.8)
Spherical equivalent	Median (range)	−1.12 (−3.5–3.25)	−1.5 (−4.25–1)	0.382
Axial length (mm)	Mean ±SD	22.9 ±0.6	23.1 ±0.8	0.482
Side	Right n (%)	15 (57.7)	13 (56.5)	0.934
	Left n (%)	11 (42.3)	10 (43.5)

Notes: Independent t-test or Mann Whitney U-test was used quantitative data. The Chi-square test was used for categorical data.

Table 2 Intraocular Pressure Before and After Injection

IOP		Group I (n = 26)	Group II (n = 23)	P-value
Before	Mean ±SD	14 ±2	15 ±3	0.093
After	Mean ±SD	15 ±2	17±4	0.071
Percent change	Median (range)	12.1 (0–33.3)	11.8 (0–50)	0.864

Notes: Independent t-test was used for pre and post-injection IOP. Mann Whitney U-test was used for percent change.

Figure 1 Intraocular pressure before and after anesthesia injection in both groups.

Figure 2 OCT-A of the DCP in patient number 4 in group II before injection of peribulbar anesthesia.

Figure 3 OCT-A of the DCP of patient number 4 in group II after injection of peribulbar anesthesia.

Figure 4 OCT-A of the FAZ of patient number 4 in group II before injection of peribulbar anesthesia.

Figure 5 OCT-A of the FAZ of patient number 4 in group II after injection of peribulbar anesthesia.

Figure 6 OCT-A of the ONH and peripapillary area of patient number 6 in group I before injection of peribulbar anesthesia.

Figure 7 OCT-A of the ONH and peripapillary area of patient number 6 in group I after injection of peribulbar anesthesia.

Figure 8 OCT-A of the ONH and peripapillary area of patient number 4 in group II before injection of peribulbar anesthesia.

Figure 9 OCT-A of the ONH and peripapillary area of patient number 4 in group II after injection of peribulbar anesthesia.

Figure 10 OCT-A of the SCP of patient number 4 in group II before injection of peribulbar anesthesia.

Figure 11 OCT-A of the SCP of patient number 4 in group II after injection of peribulbar anesthesia.

Table 3 Pre and Post-Injection OCT Parameters in Both Groups

		Group I (n = 26)	Group II (n = 23)	P-value
DCP fovea
Before	Median (range)	11.8 (7.4–18.6)	11.3 (7.8–18.4)	1.0
After	Median (range)	11.6 (7.2–18.1)	7.1 (0.5–17.9)	<0.001
Percent change	Median (range)	−2.5 (−6.9–−0.6)	−43.5 (−94.5–−2.2)	<0.001
DCP total density
Before	Mean ±SD	39 ±3.7	37.1 ±3	0.053
After	Mean ±SD	38.6 ±3.7	27.8 ±5.7	<0.001
Percent change	Median (range)	−0.9 (−3.1–0)	−21 (−50–−0.7)	<0.001
FAZ (mm^2)
Before	Mean ±SD	0.444 ±0.042	0.42 ±0.047	0.061
After	Mean ±SD	0.454 ±0.046	0.572 ±0.042	<0.001
Percent change	Median (range)	2.5 (−3.3–6.1)	40.6 (3.2–63.9)	<0.001
ONH total vessel density
Before	Mean ±SD	32.1 ±2.4	29 ±1.9	<0.001
After	Mean ±SD	30.7±6.1	25.3 ±4.4	0.001
Percent change	Median (range)	−1.1 (−89.3–0)	−13.6 (−39.5–16.5)	<0.001
ONH peripapillary density
Before	Mean ±SD	27.8 ±2.5	27.4 ±3	0.637
After	Mean ±SD	27.4 ±2.5	23.4 ±3.7	<0.001
Percent change	Median (range)	−1.2 (−2.9–−0.3)	−13.1 (−31.2–−1.9)	<0.001
SCP fovea
Before	Median (range)	9.4 (5–13)	7.3 (2.7–13.4)	0.017
After	Median (range)	9.3 (4.8–12.4)	1.9 (0–8.7)	<0.001
Percent change	Median (range)	−2.6 (−9–0)	−62.6 (−100–56.2)	<0.001
SCP total density
Before	Mean ±SD	29.3 ±2.6	32 ±3	0.001
After	Mean ±SD	28.9 ±2.6	27 ±3.4	0.031
Percent change	Median (range)	−1.1 (−4–0)	−16.2 (−26–−1.7)	<0.001

Note: Independent t-test or Mann Whitney U-test was used.

Figure 12 OCT-A of the SCP of patient number 7 in group I before injection of peribulbar anesthesia.

Figure 13 OCT-A of the SCP of patient number 7 in group I after injection of peribulbar anesthesia.

Figure 14 Pre and post-injection OCT-A parameters in both groups.