Reduction of Myopic Progression Using a Multifocal Soft Contact Lens: A Retrospective Cohort Study

Figures & data

Figure 1 Change over time in refractive error (D) while wearing NaturalVue Multifocal lenses compared with baseline annualized myopic progression. Refractive error at all time points differed significantly when compared with baseline (P < 0.0001).

Table 1 Baseline Demographic Characteristics of Age-Matched NaturalVue Multifocal Wearers and Subjects in the MiSight and BLINK Trials^17,18,25

	BLINK Control Group Biofinity Single Vision, N = 98	MiSight Control Group Proclear 1 Day, N = 74	BLINK Test Group Biofinity CD +2.50Add, N = 98	MiSight Test Group MiSight 1 Day, N = 70	NaturalVue Multifocal, N = 82
Age
Mean, SD	10.3 (1.1)	10.1 (1.3)	10.3 (1.2)	10.1 (1.4)	10.3 (1.2)
Number (%) aged 8–10 years	39 (39.8%) Note: ages 7–9	42 (57%)	39 (39.8%) Note: ages 7–9	40 (57%)	46 (56%)
Number (%) aged 11–12 years	59 (60.2%) Note: ages 10–11	32 (43%)	59 (60.2%) Note: ages 10–11	30 (43%)	36 (44%)
Sex Number (%)
Female	64 (65.3%)	37 (50%)	64 (65.3%)	38 (54%)	48 (59%)
Male	34 (34.7%)	37 (50%)	34 (34.7%)	32 (46%)	34 (41%)
Ethnicity Number (%)
Caucasian	59 (60.2%)	40 (54%)	64 (65.3%)	39 (56%)	47 (57%)
East Asian/Asian	9 (9.2%)	18 (24%)	9 (9.2%)	16 (23%)	25 (30%)
Indian/Pakistani/Sri Lankan	NR	7 (9%)	NR	5 (7%)	4 (5%)
Other	19 (19.4%)	4 (5%)	9 (9.2%)	2 (3%)	4 (5%)
Mixed	11 (11.2%)	5 (7%)	13 (13.3%)	8 (11%)	2 (3%)

Abbreviations: SD, standard deviation; NR, not reported.

Table 2 Comparison of Myopic Progression Over 3 Years for Age-Matched NaturalVue Multifocal Wearers and Subjects in the MiSight and BLINK Trials^17,18,25

Refractive Error Change from Baseline to 3 Years	MiSight Control Proclear 1 Day, N = 112 Eyes		MiSight, N =104 Eyes		BLINK Control Biofinity Single Vision, N = 96 eyes	BLINK Biofinity CD +2.50D Add, N = 95 Eyes	NaturalVue MF N=66 Eyes with Data Available Through 3 Years
	n	%	n	%			n	%
−0.25 D or less	4	3.6%	43	41.3%	NR	NR	60	91%
−0.50 D or less	11	9.8%	57	54.8%	NR	NR	66	100%
−0.75 D or less	30	26.8%	70	67.3%	NR	NR	66	100%
−1.00 D or less	43	38.4%	85	81.7%	NR	NR	66	100%
> −1.00D	63	61.6%	19	18.3%	51%≥ −1.00	16.8%≥ −1.00	0	0%

Abbreviations: D, diopter; NR, not reported.

Figure 2 Annual myopic refractive error progression in wearers of NaturalVue multifocal lenses and age and ethnicity matched virtual myopic controls from published meta-analyses.^30–34

Figure 3 Annual axial elongation in wearers of NaturalVue multifocal lenses and age and ethnicity matched virtual myopic controls from published meta-analyses.^30–34

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