Treatment of Non-Infectious Posterior Uveitis with Dexamethasone Intravitreal Implants in a Real-World Setting

Figures & data

Table 1 The Characteristics of the Patients and the Affected Eyes at Baseline, the Number of DEX Implants, Unstratified and Stratified According to the Presence or Absence of Cataract

Characteristic			Total (N=38)
Lens status, n (%)
Phakic			24 (63.2%)
Pseudophakic			14 (36.8%)
Eyes receiving immunosuppressor therapy, n (%)			10 (26.3%)
Eyes receiving IOP lowering medication, n (%)			8 (21.1%)
Mean VA, logMAR (SD)			0.7 (0.5)
Mean CRT, μm (SD)			439.5 (117.8)
Number of implants			Number of eyes
1			13
2			9
3			3
4			3
5			1
6			2
9			1
10			1
14			1
19			1
22			1
26			2
Cataracts	N	Median	Mean [95% CI]	P value
No cataract	29	2	5.8 [3.0, 8.6]
Cataract	9	2	3.0 [1.4, 4.6]	p = 1.000

Abbreviations: VA, Visual acuity; logMAR, logarithm of the minimum angle of resolution; CRT, Central retinal thickness.

Table 2 Visual Acuity Outcomes (logMAR) After Administering DEX Implants at the Follow-Up Time Points, Stratified According to the Number of DEX Implants Received and the Presence or Absence of a Cataract

No. of implants	Time point	N	Median [25%, 75%]	Mean [95% CI]	P value
1	Baseline	12	0.6 [0.5, 0.85]	0.7 [0.5, 0.9]
	6 weeks	13	0.4 [0.2, 0.8]	0.6 [0.3, 0.8]	p = 0.271
	6 months	12	0.5 [0.275, 0.8]	0.6 [0.3, 0.9]	p = 0.514
2–6	Baseline	15	0.6 [0.45, 0.75]	0.6 [0.4, 0.7]
	6 weeks	14	0.25 [0.2, 0.5]	0.3 [0.2, 0.4]	p = 0.009
	6 months	15	0.5 [0.25, 0.75]	0.7 [0.3, 1.1]	p = 0.916
9–26	Baseline	6	0.3 [0.225, 0.525]	0.7 [−0.2, 1.6]
	6 weeks	4	0.15 [−0.025, 0.3]	0.1 [−0.1, 0.3]	p = 0.174
	6 months	5	0.3 [0.3, 0.6]	0.4 [0.1, 0.7]	p = 0.423
Cataracts	Time point	N	Median [25%, 75%]	Mean [95% CI]	P value
No cataract	Baseline	24	0.55 [0.475, 0.8]	0.7 [0.5, 0.9]
	6 weeks	23	0.3 [0.2, 0.6]	0.4 [0.3, 0.6]	p = 0.032
	6 months	23	0.4 [0.2, 0.8]	0.6 [0.3, 0.8]	p = 0.679
Cataract	Baseline	9	0.6 [0.2, 0.7]	0.5 [0.3, 0.8]
	6 weeks	8	0.25 [0.15, 0.425]	0.3 [0.1, 0.4]	p = 0.058
	6 months	9	0.6 [0.3, 0.6]	0.8 [0.2, 1.4]	p = 0.678

Table 3 CRT (µm) Outcomes After DEX Implants at the Follow-Up Time Points, Stratified According to the Number of DEX Implants Received and According to the Presence or Absence of a Cataract

No. of implants	Time point	N	Median [25%, 75%]	Mean [95% CI]	P value
1	Baseline	12	469 [331, 571.25]	467.6 [380.4, 554.8]
	6 weeks	12	319 [281.5, 378.5]	326.5 [279.3, 373.7]	p = 0.003
	6 months	11	299 [281, 393.5]	352.2 [268.9, 435.5]	p = 0.054
2–6	Baseline	17	442 [397, 474]	445.4 [405.8, 485.0]
	6 weeks	17	297 [268, 330]	331.8 [278.1, 385.4]	p < 0.001
	6 months	18	405.5 [311.25, 433]	372.7 [336.1, 409.4]	p = 0.001
9–26	Baseline	5	337 [276, 389]	352.2 [267.4, 437.0]
	6 weeks	5	317 [243, 342]	298.4 [244.0, 352.8]	p = 0.062
	6 months	5	329 [258, 358]	350.2 [232.8, 467.6]	p = 0.625
Cataracts	Time point	N	Median [25%, 75%]	Mean [95% CI]	P value
No cataract	Baseline	25	429 [337, 474]	425.3 [378.3, 472.3]
	6 weeks	25	310 [268, 344]	322.8 [283.6, 362.0]	p < 0.001
	6 months	25	344 [288, 430]	366.6 [321.4, 411.7]	p = 0.006
Cataract	Baseline	9	490 [433, 530]	479.0 [408.2, 549.8]
	6 weeks	9	322 [275, 342]	331.1 [274.5, 387.7]	p = 0.004
	6 months	9	329 [299, 430]	352.2 [295.1, 409.3]	p = 0.004

Figure 1 Plots of the development of the different parameters assessed over the course of the follow up. (A) Median VA over time, stratified according to the number of implants. (B) Median VA (logMAR) over time, stratified according to the presence or absence of a cataract. (C) Median CRT (µm) over time, stratified according to the number of implants. (D) Median CRT (µm) over time, stratified according to the presence or absence of a cataract. (E) Median IOP over time, stratified according to the number of implants. (F) Median IOP over time, stratified according to the presence or absence of a cataract. The error bars represent the 25th and 75th percentile values.

Table 4 IOP (mmHg) After DEX Implants at the Follow-Up Time Points, Stratified According to the Number of DEX Implants Received and According to the Presence or Absence of a Cataract

No. of implants	Time point	N	Median [25%, 75%]	Mean [95% CI]	P value
1	Baseline	12	14.5 [12.75, 18.5]	14.4 [11.1, 17.7]
	6 weeks	12	17.5 [15, 23.25]	19.8 [15.8, 23.7]	p = 0.024
	6 months	11	15 [13.5, 16.5]	17.2 [11.5, 22.9]	p = 0.634
2–6	Baseline	14	14.5 [12, 17.5]	15.1 [11.9, 18.3]
	6 weeks	12	15.5 [12, 18.5]	17.1 [12.0, 22.2]	p = 0.220
	6 months	15	15 [12, 16]	15.7 [12.4, 19.0]	p = 0.755
9–26	Baseline	5	14 [14, 14]	14.2 [11.4, 17.0]
	6 weeks	5	18 [17, 19]	18.2 [16.5, 19.9]	p = 0.125
	6 months	5	12 [11, 15]	14.0 [9.8, 18.2]	p = 0.855
Cataracts	Time point	N	Median [25%, 75%]	Mean [95% CI]	P value
No cataract	Baseline	22	14 [12, 16.5]	14.1 [11.6, 16.6]
	6 weeks	21	17 [15, 20]	18.5 [15.2, 21.9]	p = 0.006
	6 months	22	14.5 [12, 16]	15.1 [12.7, 17.5]	p = 0.499
Cataract	Baseline	9	16 [12, 18]	16.1 [13.4, 18.9]
	6 weeks	8	16.5 [14.75, 18.5]	18.0 [13.7, 22.3]	p = 0.293
	6 months	9	15 [12, 18]	18.0 [11.1, 24.9]	p = 1.000