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ORIGINAL RESEARCH

Morphological Macular Changes Under Brolucizumab Treatment for Neovascular Age-Related Macular Degeneration Refractory to Previous Anti-VEGF Treatment Compared with Treatment-Naive Eyes

, , , , , & show all
Pages 769-777 | Received 05 Nov 2022, Accepted 19 Jan 2023, Published online: 08 Mar 2023

Figures & data

Table 1 General Demographics and Results of All the Eyes at Baseline

Figure 1 Mean changes in the BCVA (logMAR) in treatment-naive and refractory treatment groups from baseline to the different visits. Statistical significant increase in the BCVA was seen in the TN group only, after the loading phase from the baseline and after 8th IVI from the loading phase.*Statistically significant result.

Abbreviations: BCVA, best corrected visual acuity; TN, treatment naive; RT, refractory treatment.
Figure 1 Mean changes in the BCVA (logMAR) in treatment-naive and refractory treatment groups from baseline to the different visits. Statistical significant increase in the BCVA was seen in the TN group only, after the loading phase from the baseline and after 8th IVI from the loading phase.*Statistically significant result.

Figure 2 Mean changes in the FCT in the treatment-naive and refractory treatment groups from baseline to the different visits. Statistically significant reduction in the FCT was seen in both groups after the loading phase, however, further significant reduction in the FCT was only seen in the TN group 8th IVI from the loading phase. *Statistically significant result.

Abbreviations: FCT, foveal central thickness; TN, treatment naive; RT, refractorytreatment.
Figure 2 Mean changes in the FCT in the treatment-naive and refractory treatment groups from baseline to the different visits. Statistically significant reduction in the FCT was seen in both groups after the loading phase, however, further significant reduction in the FCT was only seen in the TN group 8th IVI from the loading phase. *Statistically significant result.

Table 2 Results of All Eyes in the Treatment-Naive and Refractory Treatment Groups at the Different Visits Schedules