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Clinical Ophthalmology Volume 17, 2023 - Issue
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ORIGINAL RESEARCH

Effects of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms on Retinal Tissue Perfusion in Mild Diabetic Retinopathy Patients Receiving the Medical Food, Ocufolin®

Hong Jiang1 Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA;2 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USAView further author information
,
Zhiping Liu1 Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA;3 Ophthalmic Center, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-9497-4161View further author information
ORCID Icon,
Justin H Townsend1 Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USAORCID Iconhttps://orcid.org/0000-0001-6064-5458View further author information
ORCID Icon &
Jianhua Wang1 Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence[email protected]
View further author information
Pages 1121-1127 | Received 05 Jan 2023, Accepted 27 Mar 2023, Published online: 12 Apr 2023

Figures & data

Figure 1 Effects of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on retinal tissue perfusion (A) RTP and blood flow (B) RBF in mild diabetic retinopathy patients with methylenetetrahydrofolate reductase polymorphisms (DR + PM) patients receiving the medical food during follow-up periods. In patients with A1298C mutation, all vascular metrics (including RTP and RBF) were improved over the Baseline at 4 months and 6 months, but the peak benefit was at four months (all P < 0.05). In patients with C677T and C677T/A1298C compound mutations, RTP at 6 months significantly increased as compared to those at baseline and 4 months. Bars = standard error.

Figure 1 Effects of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on retinal tissue perfusion (A) RTP and blood flow (B) RBF in mild diabetic retinopathy patients with methylenetetrahydrofolate reductase polymorphisms (DR + PM) patients receiving the medical food during follow-up periods. In patients with A1298C mutation, all vascular metrics (including RTP and RBF) were improved over the Baseline at 4 months and 6 months, but the peak benefit was at four months (all P < 0.05). In patients with C677T and C677T/A1298C compound mutations, RTP at 6 months significantly increased as compared to those at baseline and 4 months. Bars = standard error.

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