Endothelial Cell Loss Following Cataract Surgery Using Continuous Curvilinear Capsulorhexis or Precision Pulse Capsulotomy

Figures & data

Table 1 Cataract Grade, ACD, UCVA and BCVA

Cataract Grade (LOCS II)	CCC	PPC	Chi-Square
Grade 1	6.1%	5.9%	P=0.909
Grade 2	63.6%	58.8%
Grade 3	30.3%	35.3
ACD	Mean (mm)	SD (mm)	Range (mm)	T-test
CCC	3.17	0.38	2.57–4.13	P=0.303
PPC	3.07	0.38	2.16–3.75
UCVA	LogMAR	Mean	SD	Range	T-test
Pre-op	CCC	0.59	0.43	0.18–2.0	P=0.338
	PPC	0.68	0.34	0.10–1.40
1-month	CCC	0.14	0.16	0.00–0.70	P=0.655
	PPC	0.16	0.14	0.00–0.60
3-months	CCC	0.12	0.15	0.00–0.60	P=0.310
	PPC	0.16	0.19	0.00–0.60
BCVA	LogMAR	Mean	SD	Range	T-test
Pre-op	CCC	0.36	0.39	0.00–2.00	P=0.645
	PPC	0.33	0.22	0.00–1.00
1-month	CCC	0.03	0.07	−0.10–0.30	P=0.081
	PPC	0.07	0.132	−0.10–0.54
3-months	CCC	0.012	0.06	−0.10–0.10	P=0.068
	PPC	0.06	0.13	−0.12–0.54

Table 2 ECD Loss at 1 and 3 Months After Cataract Surgery Using CCC or PPC

Observation Period	Group	ECD Loss (Mean)	T-test	95% CI	SD (Cells/mm^2)	25th Percentile ECD Loss	50th Percentile ECD Loss	75% Percentile ECD Loss
1 month	CCC (n=33)	11.5%	P=0.818	(7.0–16.0)	±335	3.5	9.8	16.4
	PPC (n=33)	12.3%		(7.2–17.3)	±345	2.3	8.8	20.8
3 months	CCC (n=33)	11.7%	P=0.815	(7.7–15.7)	±295	4.6	8.5	15.7
	PPC (n=33)	12.4%		(7.5–17.4)	±337	2.0	7.0	20.1

Table 3 The Mean Percentage of Hexagonal Cells and CV in Cell Size at Pre-op, 1 Month, and 3 Months in CCC and PPC Groups

Observation Period	Capsulotomy Method	% Hexagonal Cells	T-test	CV	T-test
Pre-Op	CCC (n=33)	58.0	P=0.826	32.8	P=0.1309
	PPC (n=33)	58.3		34.0
1 month	CCC (n=33)	54.3	P=0.695	34.3	P=0.9270
	PPC (n=33)	54.7		33.8
3 months	CCC (n=33)	56.2	P=0.278	32.4	P=0.864
	PPC (n=33)	54.6		33.5

Table 4 Literature Survey with Mean Percentage of ECD Loss at 1 and 3 Months After Cataract Surgery with Phacoemulsification

Study	Observation Period	ECD Loss (Mean)
Acar et al 2011	1 mo	5.5%
	3 mo	9.2%
Hwang et al 2015	2 mo	11.3%
Dewan et al 2019	1 mo	22%
	3 mo	22.8%
Kim and Kim 2010	1 mo	7.9%
	3 mo	8.5%
Gogate et al 2010	1.5 mo	18%
Teoh et al 2017	3 mo	19.4%
Tsuneoka et al	3 mo	9.5%
Reuschel et al 2010	3 mo	7.2%
Mahdy et al 2012	3 mo	16.7%
Current Study	1 mo	11.5% (CCC)
		12.3% (PPC)
	3 mo	11.7% (CCC)
		12.4% (PPC)