Association of Treatment Duration and Clinical Outcomes in Dry Eye Treatment with Sutureless Cryopreserved Amniotic Membrane

Figures & data

Table 1 DEWS Scores by Treatment Duration with Cryopreserved Amniotic Membrane (cAM)

cAM Duration	Baseline	1 Week	1 Month	3 Months	P-value
2 days (n=10)	3.10 ± 0.57	1.50 ± 0.53	1.20 ± 0.42	1.20 ± 0.42	<0.0001
3 days (n=15)	3.27 ± 0.59	1.40 ± 0.91	1.47 ± 0.83	1.47 ± 0.83	<0.0001
4 days (n=12)	3.25 ± 0.62	1.58 ± 0.51	1.33 ± 0.49	1.58 ± 0.51	<0.0001
5 days (n=19)	3.42 ± 0.61	1.42 ± 0.51	1.44 ± 0.62	1.26 ± 0.56	<0.0001
6 days (n=6)	3.17 ± 0.75	1.67 ± 1.03	1.33 ± 0.52	1.83 ± 0.75	0.031
7 days (n=27)	3.15 ± 0.46	1.37 ± 0.56	1.62 ± 0.75	1.59 ± 0.57	<0.0001
TOTAL (n=89)	3.24 ± 0.56	1.45 ± 0.65	1.45 ± 0.65	1.47 ± 0.63	<0.0001
P-value	0.65	0.88	0.62	0.19

Figure 1 Corneal Staining Scores Following cAM Treatment. Corneal staining scores significantly improved from baseline at 1 week, 1 month, and 3 months for both the 2-day treatment group (n=10) and the overall study sample (n=89), with no significant differences observed between groups at any timepoint. **Denotes p<0.01 when compared to baseline.

Figure 2 Ocular Discomfort Scores Following cAM Treatment. Ocular discomfort scores significantly improved from baseline at 1 week, 1 month, and 3 months post-treatment for both the 2-day treatment group (n=10) and the overall study sample (n=89), with no significant differences observed between groups at any timepoint. **Denotes p<0.01 when compared to baseline.

Figure 3 Visual Symptom Scores Following cAM Treatment. Visual symptom scores significantly improved from baseline at 1 week, 1 month, and 3 months post-treatment for both the 2-day treatment group (n=10) and the overall study sample (n=89), with no significant differences observed between groups at any timepoint. *Denotes p<0.05 when compared to baseline.

Figure 4 Representative Case. A 62-year-old male presented with moderate DED (DEWS 3) demonstrated by positive fluorescein staining (A). After 2 day treatment with cAM, the ocular surface healed with a stable tear film and clear cornea (B).