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Clinical Ophthalmology Volume 17, 2023 - Issue
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ORIGINAL RESEARCH

Characterizing Macular Neovascularization in Myopic Macular Degeneration and Age-Related Macular Degeneration Using Swept Source OCTA

Diane N Sayah1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA;3 College of Optometry, University of Houston, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-3734-403X
ORCID Icon,
Itika Garg1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0002-9537-8561
ORCID Icon,
Raviv Katz1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0002-5305-8551
ORCID Icon,
Ying Zhu1 Harvard Retinal Imaging Lab, Boston, MA, USA;4 Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Ying Cui1 Harvard Retinal Imaging Lab, Boston, MA, USA;5 Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China
,
Rebecca Zeng1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Rachel Tandias1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Jade Y Moon1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Filippos Vingopoulos1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0003-3778-5473
ORCID Icon,
Hannah E Wescott1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Grace Baldwin1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Kira Wang1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Tobias Elze1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
,
Cassie Ann Ludwig1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
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Demetrios G Vavvas1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
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Joan W Miller1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
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Deeba Husain1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0002-8494-0950
ORCID Icon,
Leo A Kim1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0001-9106-6416
ORCID Icon,
Nimesh A Patel1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
&
John B Miller1 Harvard Retinal Imaging Lab, Boston, MA, USA;2 Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0109-9738
ORCID Icon show all
Pages 3855-3866 | Received 11 Oct 2023, Accepted 27 Nov 2023, Published online: 12 Dec 2023

Figures & data

Figure 1 Morphologic patterns of macular neovascularization (MNV) as visualized using swept-source OCT Angiography. Shape descriptors included (A) the “Medusa” pattern representing a lesion where vessels radiate in all directions; (B) the “Sea-fan” pattern representing a lesion where blood vessels radiate in all directions from one side; and (C) the “Tree-in-bud” pattern representing a round lesion with no obvious vascular trunk. Images were also evaluated for the presence of (D) peripheral loops (indicated by the yellow arrows), (E) capillary fringe (indicated by the yellow arrows), a perilesional dark halo (indicated by the box) and (F) a core vessel (indicated by the yellow arrows).

Figure 1 Morphologic patterns of macular neovascularization (MNV) as visualized using swept-source OCT Angiography. Shape descriptors included (A) the “Medusa” pattern representing a lesion where vessels radiate in all directions; (B) the “Sea-fan” pattern representing a lesion where blood vessels radiate in all directions from one side; and (C) the “Tree-in-bud” pattern representing a round lesion with no obvious vascular trunk. Images were also evaluated for the presence of (D) peripheral loops (indicated by the yellow arrows), (E) capillary fringe (indicated by the yellow arrows), a perilesional dark halo (indicated by the box) and (F) a core vessel (indicated by the yellow arrows).

Table 1 Summary of Demographic and Clinical Characteristics for Eyes with MNV Secondary to Myopic Macular Degeneration (MMD) and Eyes with MNV Secondary to Age-Related Macular Degeneration (AMD)

Table 2 Summary of Qualitative and Quantitative Assessment of MNV Morphology Secondary to Myopic Macular Degeneration (MMD) and Age-Related Macular Degeneration (AMD) Using SS-OCTA

Table 3 Univariate Regression Analysis of MNV Area and Vessel Density

Table 4 Characteristics of Treatment-Naïve MNVs in Eyes with Discernible Lesions on En-Face SS-OCTA

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