Early Real-World Patient and Staff Experience with an Intracanalicular Dexamethasone Insert

Figures & data

Figure 1 Dexamethasone intracanalicular insert depicted in yellow (coin for scale) (A). Placement of the dexamethasone intracanalicular insert in the canaliculus of the eye (B). The dexamethasone intracanalicular insert can be visualized by a blue light source (for example, slit lamp or hand-held blue light) with a yellow filter (C).

Table 1 Patient Demographics

Characteristics, n (%)	N=62
Age (years)
51–55	3 (5%)
56–60	8 (13%)
61–65	9 (15%)
66–70	17 (27%)
71–75	15 (24%)
>75	9 (15%)
No answer	1 (2%)
Gender
Female	37 (60%)
Male	25 (40%)
Comorbidities
Glaucoma or history of elevated IOP	6 (10%)
Uveitis	0 (0%)
Dry eye	20 (32%)
Floppy iris syndrome	0 (0%)
Parkinson disease or motor impairment	2 (3%)
Psychiatric Disorder	1 (2%)
No Comorbidities	36 (58%)
Employment status
Working or student	16 (26%)
Not working (not retired)	0 (0%)
Retired	40 (65%)
On disability	3 (5%)
Prefer not to answer	3 (5%)
Insurance Type
Medicaid	3 (5%)
Private insurance	16 (26%)
Medicare	41 (66%)

Abbreviation: IOP, intraocular pressure.

Figure 2 Proportion of patients reporting (A) prescribed schedule and (B) proper instillation of eyedrops combined with DEX after cataract surgery. More than 38% of patients reported that it was difficult to take all eyedrops exactly when they were supposed to be applied (A), and more than 40% of patients reported that it was difficult to apply all eye drops exactly into their eye every time (B).

Figure 3 Proportion of patients who reported missing instillation of prescribed eyedrops combined with DEX after cataract surgery. Patients reported missing at least 1 eyedrop instillation of prescribed eyedrops after surgery.

Figure 4 (A) Satisfaction, (B), preference, and (C) likelihood of recommending DEX to family members of patients at 30 days from DEX placement. (A) and (C) were scored on a 7-point Likert scale and (B) was a multiple-choice question. Patients were generally satisfied with having DEXTENZA during cataract surgery (A), would prefer DEXTENZA over 4 additional eye drops per day (B), and were likely to recommend DEXTENZA to a family member for post-cataract surgery pain control (C).

Figure 5 Proportion of practice staff representatives who reported patients having difficulty with a type of ocular medication. Patients more frequently had difficulty with steroid medications compared to NSAIDs or antibiotics. NSAID, non-steroidal anti-inflammatory.

Figure 6 Practice staff time spent on patient education and pharmacy callbacks reduced with DEXTENZA. (A) Practice staff spent 45% less time on patient education and (B) 46% less time on pharmacy calls with DEXTENZA compared to the standard of care 3-drop regimen.

Table 2 Satisfaction of Practice Staff Representatives (N = 19) with DEXTENZA

Characteristics	Neither Dissatisfied nor Satisfied (Rating=4)n (%)	Satisfied (Rating=5)n (%)	Very Satisfied (Rating=6)n (%)	Extremely Satisfied (Rating=7)n (%)
DEXTENZA provides adequate pain control post-surgery	4 (21)	0 (0)	1 (33)	3 (30)
Intracanalicular inserts are a preferred way to achieve sustained drug delivery	4 (21)	1 (17)	0 (0)	3 (30)
DEXTENZA reduces inflammation	8 (42)	2 (33)	1 (33)	5 (50)
DEXTENZA improves patient compliance (fewer drops)	18 (95)	6 (100)	2 (67)	10 (100)
DEXTENZA may make recovery more convenient for the patient	15 (79)	5 (83)	1 (33)	9 (90)
DEXTENZA can be used in a variety of cataract patients	13 (68)	2 (33)	1 (33)	10 (100)
DEXTENZA can be used in various ocular surgeries	4 (21)	1 (17)	1 (33)	2 (20)
DEXTENZA is FDA approved providing evidence of good safety and tolerability	8 (42)	2 (33)	1 (33)	5 (50)
DEXTENZA reduces patient callback time	11 (58)	3(50)	0 (0)	8 (80)

Abbreviation: FDA, Food and Drug Administration.

Figure 7 Satisfaction of practice staff representatives with using DEXTENZA as a new means of providing 30 days of steroid treatment for patients undergoing cataract surgery. Scores are based on 7-point Likert scale with 1 being highly dissatisfied, 4 being neither dissatisfied nor satisfied, and 7 being highly satisfied. Approximately 95% of practice staff representatives were satisfied to highly satisfied.