Quantification of Metamorphopsia in Resolved Idiopathic Central Serous Chorioretinopathy: An Analysis Using M-CHARTS, Amsler Grid, and Optical Coherence Tomography

Figures & data

Table 1 Baseline Characteristics of the Metamorphopsia and Non-Metamorphopsia Group

Baseline Characteristics	Metamorphopsia Group	Non-Metamorphopsia Group	p-value^#
Age (in years)	n=20, 45.65 ± 8.10	n=18, 45.83 ± 8.40	0.815
Best Corrected Visual Acuity (logarithm of the minimum angle of resolution)	n=22, 0.19 ± 0.25	n=19, 0.12 ± 0.16	0.359
Central Macular Thickness	n=22, 245.59 ± 34.88	n=19, 243.16 ± 43.32	0.906
Mean M- CHARTS Vertical (V) Score	n=22, 0.414 ± 0.352	n=19, 0.026 ± 0.065	0.000*
Mean M- CHARTS Horizontal (H) Score	n=22, 0.413 ± 0.382	n=19, 0.011 ± 0.032	0.000*
Mean scores of Vertical and Horizontal Scores	n=22, 0.827 ± 0.676	n=19, 0.036 ± 0.076	0.000*

Notes: ^#Mann–Whitney U-Test; *Statistically significant at p<0.001.

Table 2 Association Between Metamorphopsia Diagnosed by M- CHARTS and OCT Parameters

OCT Parameters		Metamorphopsia		p-value	OR (95% CI)
		Yes (%)	No (%)
Pigment Epithelial Detachment	Yes	12 (54.5)	4 (21.1)	0.028*	4.500 (1.125–17.993)
	No	10 (45.5)	15 (78.9)
Retinal Pigment Epithelial Bumps	Yes	8 (36.4)	5 (26.3)	0.491	1.600 (0.419–6.114)
	No	14 (63.6)	14 (73.7)
Hyper Reflex Dots in Intraretinal or Subretinal Layer	Yes	7 (31.8)	3 (15.8)	0.292^#	2.489 (0.542–11.436
	No	15 (68.2)	16 (84.2)
Discontinuity in Inner and Outer Segment Junction	Yes	6 (27.3)	2 (10.5)	0.249	3.188 (0.560–18.157)
	No	16 (72.7)	17 (89.5)

Notes: *Statistically significant at p<0.05. ^#Fisher’s Exact Test.

Table 3 Diagnostic Accuracy of M-CHARTS in the Detection of Metamorphopsia in Reference to Amsler Grid

Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value	Accuracy	Kappa
87.50%	68.00%	63.64%	89.47%	75.61%	0.520