Pharmacotherapy for uveitis: current management and emerging therapy

Figures & data

Table 1 List of therapeutic agents discussed in review

Category	Class	Subtypes	Examples
Corticosteroids	Corticosteroids	–	Prednisolone Methylprednisolone Iluvien Ozurdex Retisert
Second-line agents	T-cell inhibitors	Calcineurin inhibitor	Cyclosporine Tacrolimus Voclosporin
		mTOR inhibitor	Everolimus Sirolimus
	Antimetabolites	Purine antagonist DHFR inhibitor IMPDH inhibitor	Azathioprine Methotrexate Mycophenolate mofetil
	Alkylating agents	–	Chlorambucil Cyclophosphamide
Biologics	Anti-TNF	Anti-TNFα Anti-TNFα and β	Adalimumab Certolizumab Golimumab Infliximab Etanercept
	Other biologic agents	Anti-CD11a Anti-CD20 Anti-CD28 Anti-CD52 Anti-IL1 Anti-IL1β	Efalizumab Rituximab Abatacept Alemtuzumab Anakinra Canakinumab Gevokizumab
		Anti-IL2 Anti-IL6 Anti-IL17A Interferons S1P inhibitor VEGF inhibitors	Daclizumab Tocilizumab Secukinumab Interferon α/β Fingolimod Aflibercept Bevacizumab Ranibizumab
Other agents	Other	–	IVIG

Abbreviations: CD, cluster of differentiation; DHFR, dihydrofolate reductase; IL, interleukin; IMPDH, inosine monophosphate dehydrogenase; IVIG, intravenous immunoglobulin; mTOR, mammalian target of rapamycin; S1P, sphingosine-1-phosphate; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.