Travoprost with sofZia® preservative system lowered intraocular pressure of Japanese normal tension glaucoma with minimal side effects

Figures & data

Figure 1 IOP before and after travoprost with sofZia® administration.

Notes: IOP is presented as the mean ± SD. *P<0.0001 for significant change of IOP compared with baseline by repeated measures analysis of variance and multiple comparison using Tukey’s HSD test. sofZia® (Travatan® 0.004%, Alcon Laboratories, Inc., Fort Worth, TX, USA).
Abbreviations: HSD, honestly significant difference; IOP, intraocular pressure; SD, standard deviation.

Figure 2 Percentage reduction of IOP with drug administration.

Notes: IOP reduction rates are classified into four categories represented by each column:

≥30%,

≥20%,

≥10%,

<10%. Open circle (

) represents the mean ± SD. Vertical axes: Left and right axes represent cumulative and average percentage reduction of IOP, respectively.
Abbreviations: IOP, intraocular pressure; SD, standard deviation.

Figure 3 Change of IOP in three groups with drug administration.

Notes: Eyes were classified into three groups based on their baseline IOP: ○ ≥17 mmHg, ● ≥14 mmHg and 17 mmHg, × <14 mmHg. *P<0.0001 for significant change of IOP compared with each baseline by repeated measures analysis of variance and multiple comparison using Tukey’s HSD test.
Abbreviations: HSD, honestly significant difference; IOP, Intraocular pressure.

Table 1 SPK and hyperemia scores

	Baseline	4 week	8 week	12 week
Total SPK score	0.35±1.12	0.30±0.70	0.40±0.86	0.32±0.81
Superior	0.01±0.10	0.00±0.00	0.00±0.00	0.00±0.00
Nasal	0.05±0.22	0.06±0.31	0.09±0.32	0.08±0.33
Temporal	0.06±0.42	0.01±0.10	0.05±0.22	0.02±0.14
Central	0.04±0.27	0.02±0.20	0.02±0.14	0.03±0.17
Inferior	0.17±0.51†	0.21±0.48†	0.24±0.49†	0.19±0.47†
Hyperemia score	0.14±0.40	0.54±0.61*	0.53±0.61*	0.51±0.63*

Notes: Scores are indicated as mean ± SD.

* P<0.0001 for significant change of hyperemia score compared with baseline by Wilcoxon signed rank test.

† P<0.01 for significant difference of SPK score at each time point compared with other corneal area by Wilcoxon signed rank test.

Abbreviations: SD, standard deviation; SPK, superficial punctate keratopathy.

Figure 4 Cumulative incidence of subjective symptoms.

Notes: The cumulative incidence of adverse events in this study was 40.8% (by week 12). The most frequently observed event was ocular irritation [○: 26.2%, n=27], itching (●: 18.5%, n=19), foreign body sensation (×: 17.5%, n=18) and dryness (∆: 4.9%, n=5).

Table S1 IOP CHecked and Assessed in Normal tension Glaucoma by Exceptional Glaucomatologists (CHANGE) Study Group

Institution	Researcher
1. Tohoku University, Department of Ophthalmology, Miyagi, Japan	Nobuo Fuse
2. Yaoeda Eye Clinic, Niigata, Japan	Kiyoshi Yaoeda
3. Hara Eye Hospital, Tochigi, Japan	Takeshi Hara
4. Juntendo University Urayasu Hospital, Chiba, Japan	Itaru Kimura
5. The Jikei University School of Medicine Department of Ophthalmology, Tokyo, Japan	Tadashi Nakano
6. Yoshikawa Eye Clinic, Tokyo, Japan	Keiji Yoshikawa
7. Ueno Eye Clinic, Tokyo, Japan	Tairo Kimura
8. Nakano General Hospital, Tokyo, Japan	Hirotaka Suzumura
9. Fussa Hospital, Department of Ophthalmology, Tokyo, Japan	Toyoaki Tsumura
10. Nihonmatsu Eye Hospital, Tokyo, Japan	Mami Nanno
11. Matsukura Eye Clinic, Kanagawa, Japan	Shuji Matsukura
12. Nishikamakura Tanino Eye Clinic, Kanagawa, Japan	Tomihiko Tanino
13. Fukui-ken Saiseikai Hospital, Department of Ophthalmology, Fukui, Japan	Koji Nitta
14. Tajimi Iwase Eye Clinic, Gifu, Japan	Aiko Iwase
15. Yamabayashi Eye Clinic, Aichi, Japan	Shigeki Yamabayashi
16. Nissei Hospital, Department of Ophthalmology, Osaka, Japan	Reiko Sugimoto
17. H irakata Yamagishi Eye Clinic, Osaka, Japan	Kazuya Yamagishi
18. Kozaki Eye Clinic, Osaka, Japan	Jun Kozaki
19. Minami-Matsuyama Hospital, Department of Ophthalmology, Ehime, Japan	Shiro Mizoue
20. Mizoguchi Eye Clinic, Nagasaki, Japan	Takanori Mizoguchi
21. Ozaki Eye Clinic, Miyazaki, Japan	Mineo Ozaki
22. Unoki Eye Clinic, Kagoshima, Japan	Kazuhiko Unoki

Abbreviation: IOP, intraocular pressure.