Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction

Figures & data

Table 1 Composition of Brudysec^® 1.5 g

Composition	Per capsule	Percent recommended daily amount	Per three capsules	Percent recommended daily amount
Concentrated oil in omega-3 fatty acids	500 mg	–	1,500 mg	–
TG-DHA 70%	350 mg	–	1,050 mg	–
EPA 8.5%	42.5 mg	–	127.5 mg	–
DPA 6%	30 mg	–	90 mg	–
Vitamins
Vitamin A (retinol)	133.33 μg RE	16.66	400 μg RE	50
Vitamin C (ascorbic acid)	26.7 mg	33	80 mg	100
Vitamin E (d-α-tocopherol)	4 mg TE	33	12 mg α-TE	100
Essential trace elements
Zinc	1.6 mg	16.6	5 mg	50
Copper	0.16 mg	16.6	0.5 mg	50
Magnesium	0.33 mg	16.6	1 mg	50
Selenium	9.17 μg	16.6	27.5 μg	50
Other components
Tyrosine	10.8 mg	–	32.5 mg	–
Cysteine	5.83 mg	–	17.5 mg	–
Glutathione	2 mg	–	6 mg	–

Note: Brudysec^® 1.5 g, Brudy Laboratories, Barcelona, Spain.

Abbreviations: TG-DHA, triglyceride-bound docosahexaenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; RE, retinol equivalents; TE, tocopherol equivalents.

Table 2 Changes in health-related quality of life (SF-36) at the end of the study (3 months) as compared with baseline in the two study groups

Study group	Mean PCS (SD) score		Mean MCS (SD) score
	Baseline	3 months	Baseline	3 months
A, n=31*	49.16 (8.76)	47.46 (7.31)	49.20 (10.65)	47.80 (8.45)
B, n=30†	46.19 (8.25)	53.33 (5.57)	48.64 (9.20)	54.60 (5.64)
P-value	0.178	0.008	0.827	0.0005

Notes:

* Group A patients treated with placebo (control).

† Group B patients treated using dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants (Brudysec^® 1.5 g; Brudy Laboratories, Barcelona, Spain).

Abbreviations: PCS, Physical Component Summary; MCS, Mental Component Summary; SF-36, 36-Item Short Form Health Survey; SD, standard deviation.

Table 3 Mean differences in health-related quality of life (SF-36) in the two study groups at the end of the study (3 months) as compared with baseline

Study group	PCS score (3 months versus baseline)			MCS score (3 months versus baseline)
	Mean (SD)	95% CI	P-value	Mean (SD)	95% CI	P-value
A, n=31*	−1.70 (4.69)	−3.42 to 0.02	0.052	−1.41 (5.46)	−3.41 to 0.60	0.161
B, n=30†	7.14 (5.81)	4.97–9.31	0.000	5.96 (7.64)	3.10–8.81	0.0002

Notes:

* Group A patients treated with placebo (controls).

† Group B patients treated with dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants (Brudysec^® 1.5 g, Brudy Laboratories, Barcelona, Spain).

Abbreviations: PCS, Physical Component Summary; MCS, Mental Component Summary; CI, confidence interval; SF-36, 36-Item Short Form Health Survey; SD, standard deviation.