Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies

Figures & data

Figure 1 Age distribution in patients with ocular manifestations typical of rheumatoid arthritis.

Table 1 Age distribution in patients with ocular manifestations of rheumatoid arthritis

Age in years	Number of patients	Percentage
21–30	7	9%
31–40	26	34%
41–50	28	37%
51–60	10	12%
61–70	6	8%

Figure 2 Percentage distribution of ocular manifestations of rheumatoid arthritis among the total study population.

Abbreviations: FK, filamentary keratitis; EPS, episcleritis; SK, sclerosing keratitis; PUK, peripheral ulcerative keratitis.

Table 2 Demographic data and ocular manifestations of rheumatoid arthritis

Age distribution	21–40 years – 43% (33 patients) 41–60 years – 49% (38 patients) >60 years – 8% (6 patients)
Sex	60 patients (78%) – females 17 patients (22%) – males
Duration of illness	Mean duration with ocular manifestations – 5.4±2.7 years Mean duration without ocular manifestations – 2.1±1.6 years
Ocular manifestations	Dry eye 28% (54 patients) Filamentary keratitis 3% (6 patients) Episcleritis 3% (6 patients) Peripheral keratitis 1% (2 patients) Sclerosing keratitis 1% (2 patients) Scleritis 2% (4 patients) Cataract 1% (3 patients)
Number of eyes involved	392 eyes 196 patients were studied 85% patients had bilateral manifestations 15% patients had unilateral manifestations Total number of eyes with ocular manifestations −135
Schirmer’s test	Mean value in patients with manifestations – 4.2±0.7 mm Mean value in patients without manifestations – 12.34±2.5 mm
TBUT value	Mean value in patients with manifestations – 7.7±2.1 secs Mean value in patients without manifestations – 14.1±2.6 secs
Ocular staining score	Average score in patients with manifestations – 5.5±1.2 Average score in patients without manifestations – 2.5±1.5
Visual acuity	86% (67 patients) has a vision of 20/20 14% (10 patients) had vision loss

Abbreviations: secs, seconds; TBUT, tear film break-up time.

Table 3 Role of anti-CCP antibodies and ocular symptoms typical of rheumatoid arthritis

Auto-antibodies (RA factor/anti-CCP)	Ocular manifestations present	Ocular manifestations absent	Total
Present	45	31	76
Absent	32	88	120
Total	77	119	196

Abbreviations: anti-CCP antibodies, anti-cyclic citrullinated peptide antibodies; RA, rheumatoid arthritis.