Evaluation of the effect of intravitreal ranibizumab injections in patients with neovascular age related macular degeneration on retinal nerve fiber layer thickness using optical coherence tomography

Figures & data

Figure 1 Pre- and post-injection quadrant and average RNFL thickness.

Abbreviation: RNFL, retinal nerve fiber layer.

Table 1 Mean and standard deviation of signal strength, average RNFL, and quadrant RNFL thickness (in microns)

Mean (± SD)
Variables	Pre-injection	Post-injection	Difference	P-value
SS	7.1±1.62	7.6±1.84	1.7±1.34	0.18
Average RNFL	90.8±18.43	91±15.31	7.1±12.85	0.94
Superior RNFL	104±28.22	101±23.42	22.7±29.42	0.63
Nasal RNFL	72.2±28.90	75.5±25.96	26.4±19.06	0.57
Inferior RNFL	112.7±29.91	116.3±27.51	20.7±16.05	0.47
Temporal RNFL	68.6±21.68	65.7±16.93	20±14.46	0.50

Abbreviations: SS, signal strength; SD, standard deviation; RNFL, retinal nerve fiber layer.

Table 2 Mean and standard deviation of signal strength, average RNFL, and quadrant RNFL thickness (in microns) in various types of CNV

Mean (± SD)
Variable	Pre-injection	Post-injection	Difference	P-value
Occult CNV
SS	7.4±1.7	7.79±1.8	−0.42±2.3	0.44
Average RNFL	92.68±13.65	92.16±13.94	0.53±9.56	0.81
Superior RNFL	106.6±24.68	108.26±21.12	−1.6±19.7	0.72
Nasal RNFL	72.84±26.29	78.58±23.18	−5.74±33.94	0.47
Inferior RNFL	118.16±27.12	114.89±29.15	3.26±22	0.53
Temporal RNFL	67.79±17.19	61.37±13.89	6.42±20.13	0.18
Classic CNV
SS	6.5±1.58	7.6±1.8	−1±1.5	0.04
Average RNFL	86.5±26.19	87.5±18	−1±23.5	0.89
Superior RNFL	96.6±34.8	89.9±22.89	9.7±45.7	0.52
Nasal RNFL	73.5±35.25	66.8±30.17	6.7±22	0.37
Inferior RNFL	105±34.78	117.8±26.8	−12.7±30.6	0.22
Temporal RNFL	64.6±23.5	73.7±20.65	−9±27.78	0.33

Abbreviations: SS, signal strength; SD, standard deviation; RNFL, retinal nerve fiber layer; CNV, choroidal neovascular membrane.

Table 3 Mean and standard deviation of signal strength, average RNFL, and quadrant RNFL thickness (in microns) in different status of the lens

Lens status	Variables	Pre-injection	Post-injection	Difference	P-value
Phakic	SS	7.15±1.9	7.6±1.9	−0.45±2	0.34
	Average	91.15±2	92.95±15	−1.8±16	0.64
	Temporal	68.45±24.5	68.9±17.9	−0.45±28.5	0.94
	Nasal	74.85±32.6	76±28.6	−1.30±35.4	0.87
	Superior	102.65±3	104.65±22.8	−2±35.5	0.80
	Inferior	112.81±28.8	116.6±25	−3.75±28.7	0.57
Cataractous	SS	6.86±1.3	7.4±1.8	−0.57±2.4	0.56
	Average	86.4±15.9	79.9±11.5	6.57±11.6	0.19
	Temporal	68.43±16.3	54.7±9.8	13.7±15	0.05
	Nasal	63.4±21	67.4±15	−4±25.9	0.69
	Superior	102±11.9	90±14	12.7±12.8	0.39
	Inferior	106±38.6	102.57±29.5	3.4±21.5	0.69
Pseudophakic	SS	7.3±1	8.33±2	−1±3	0.62
	Average	99±13	104±9.5	−5.3±4	0.15
	Temporal	70±18	70±16.8	00±19.97	1.00
	Nasal	75±18.5	89.7±27.8	−14.3±18.6	0.31
	Superior	116±41.6	105±43	10.66±16	0.37
	Inferior	128±8.9	146±18	18±20.8	0.27

Abbreviations: SS, signal strength; RNFL, retinal nerve fiber layer.