Corneal Imaging and Densitometry Measurements in Juvenile and Adult Keratoconus Patients to Evaluate Disease Progression and Treatment Effects After Corneal Cross-Linking

Figures & data

Table 1 Mean and SD for Corneal Densitometry at Pre-Treatment and Post Treatment at 3, 6, 12 Months for Adult Group

Zone	Layers	Pre CXL, Mean (SD)	Post CXL, Mean (SD)
			3 Months	6 Months	12 Months
0–2 mm	Anterior	24.7 (8.3)	29.5 (7.1)	25.9 (7.7)	24.9 (3.1)
	Central	18.4 (2.8)	20.9 (3.3)	18.3 (2.4)	18.5 (1.8)
	Posterior	12.6 (0.7)	13.1 (1.8)	12.5 (1.2)	12.7 (1.4)
2–6 mm	Anterior	20.1 (6.1)	24.3 (6.5)	21.4 (6.8)	19.8 (2.0)
	Central	16.0 (2.8)	15.8 (2.4)	16.0 (1.7)	18.3 (2.7)
	Posterior	12.2 (0.5)	12.6 (1.1)	11.8 (1.1)	12.2 (1.1)
6–10 mm	Anterior	18.5 (4.8)	22.0 (6.4)	19.9 (6.6)	18.5 (2.9)
	Central	15.0 (2.2)	16.5 (2.6)	15.4 (2.6)	15.8 (2.1)
	Posterior	12.9 (1.4)	13.4 (2.0)	13.1 (1.8)	13.3 (1.8)

Table 2 Mean and SD for Corneal Densitometry at Pre-Treatment and Post Treatment at 3, 6, and 12 Months for Juvenile Group

Zone	Layers	Pre CXL, Mean (SD)	Post CXL, Mean (SD)
			3 Months	6 Months	12 Months
0–2 mm	Anterior	24.2 (0.8)	39.7 (20.8)	28.5 (5.4)	31.5 (14.2)
	Central	19.3 (0.6)	32.9 (22.2)	21.5 (3.0)	24.4 (11.1)
	Posterior	13.8 (0.6)	20.3 (14.6)	14.3 (1.2)	16.2 (6.8)
2–6 mm	Anterior	19.8 (0.8)	33.8 (20.6)	23.5 (4.4)	27.8 (16.4)
	Central	16.2 (0.7)	25.7 (16.2)	17.8 (1.7)	21.0 (10.7)
	Posterior	12.6 (0.8)	17.4 (11.4)	12.9 (1.1)	14.4 (5.3)
6–10 mm	Anterior	18.5 (1.9)	23.3 (6.4)	19.1 (2.9)	26.09 (11.0)
	Central	14.9 (1.3)	18.2 (7.0)	14.6 (1.7)	16.7 (5.2)
	Posterior	12.2 (1.2)	14.3 (5.4)	12.0 (1.7)	12.7 (2.6)

Figure 1 Corneal densitometry diversity at 3, 6 and 12 months post treatment for both groups. (A) Adult and (B) Juvenile in the different corneal zones and layers (* significant from pre-treatment and # represent significant from 3 months post treatment at level P<0.05).

Figure 2 Corneal thickness (CCT) and thinnest area (THA) diversity between pre-treatment and all post-treatment period at each group.

Figure 3 Diversity on BCVA between pre-treatment and post-treatment both in the adult and juvenile groups (*significant from pre-treatment at P<0.05).