Quality of Life in Digital Device Users Who are Treated with Systane Hydration PF

Figures & data

Figure 1 Participant Flow Diagram.

Table 1 Digital Device Use in Participants Treated with Systane Hydration PF

Digital Device	Day 1 Hours (Mean ± SD)	Day 2 Hours (Mean ± SD)	Day 3 Hours (Mean ± SD)	Day 4 Hours (Mean ± SD)	Day 5 Hours (Mean ± SD)	1 Week Hours (Mean ± SD)	2 Weeks Hours (Mean ± SD)	P-value
Computer	5.8 ± 2.7	6.7 ± 2.9	4.8 ± 3.3	4.8 ± 2.8	5.4 ± 3.2	5.6 ± 3.0	4.8 ± 2.9	0.51
Phone	3.8 ± 2.0	3.9 ± 2.6	3.9 ± 2.1	4.1 ± 2.2	3.6 ± 2.5	3.8 ± 2.9	3.3 ± 2.1	0.04
TV	1.6 ± 1.3	1.4 ± 1.4	2.0 ± 2.0	1.4 ± 1.7	1.5 ± 1.5	1.8 ± 1.6	1.3 ± 1.5	0.47
Tablet	1.3 ± 2.3	1.0 ± 1.8	1.0 ± 2.2	1.2 ± 2.1	1.4 ± 2.5	1.8 ± 2.7	1.5 ± 2.3	0.64
Mean Total	12.4 ± 3.9	11.9 ± 4.5	10.8 ± 5.4	11.5 ± 4.1	11.9 ± 5.5	12.9 ± 5.0	10.7 ± 4.2	0.08

Abbreviation: SD, standard deviation.

Table 2 Eye Comfort Visual Analog Scale (VAS) Scores in Digital Eye Strain Participants with Dry Eye Treated with Systane Hydration PF

Question	Day 1 VAS Score (Mean ± SD)	Day 2 VAS Score (Mean ± SD)	Day 3 VAS Score (Mean ± SD)	Day 4 VAS Score (Mean ± SD)	Day 5 VAS Score (Mean ± SD)	1 Week VAS Score (Mean ± SD)	2 Weeks VAS Score (Mean ± SD)	P-value
Eye Comfort Upon Waking	60.5 ± 26.8	63.2 ± 26.6	64.2 ± 27.1	69.4 ± 26.4	71.3 ± 23.7	73.3 ± 23.0	69.5 ± 26.5	0.003
Eye Comfort at Beginning of Digital Device Use	63.1 ± 26.6	66.7 ± 23.6	70.8 ± 22.2	73.3 ± 23.0	74.4 ± 21.0	76.6 ± 18.9	75.1 ± 19.0	<0.0001
Eye Comfort at Midday of Digital Device Use	63.0 ± 18.7	65.8 ± 19.0	68.5 ± 17.9	72.4 ± 18.9	73.0 ± 18.0	74.2 ± 17.0	74.8 ± 18.5	<0.0001
Eye Comfort at End of Digital Device Use	57.4 ± 21.9	61.3 ± 21.2	61.5 ± 23.6	66.7 ± 23.3	68.7 ± 19.3	69.1 ± 20.4	75.7 ± 17.4	<0.0001
End of Day Eye Comfort	56.9 ± 21.5	62.8 ± 21.8	67.0 ± 23.7	71.4 ± 23.3	70.9 ± 19.8	71.6 ± 19.7	74.9 ± 19.3	<0.0001

Abbreviations: SD, standard deviation; VAS, visual analog scale.

Table 3 Standardized Symptoms Questionnaire Scores by Study Visit

Clinical Test	Baseline (Mean ± SD)	Week 1 (Mean ± SD)	Week 2 (Mean ± SD)	P-value
Impact of Dry Eye on Daily Life questionnaire
Daily Activities (Units: 0 to 100)*	83.8 ± 5.4	88.8 ± 6.1	91.7 ± 5.6	<0.0001
Feelings (Units: 0 to 100)*	82.9 ± 11.1	88.1 ± 11.5	90.0 ± 11.9	<0.0001
Work (Units: 0 to 100)*	59.0 ± 12.8	74.0 ± 15.0	81.4 ± 12.7	<0.0001
Ocular Surface Disease Index (Units: 0 to 100)†	24.8 ± 6.0	16.3 ± 7.4	14.3 ± 8.6	<0.0001

Notes: *Higher numbers indicate better scores; †Lower scores indicate better scores.

Abbreviation: SD, standard deviation.

Table 4 Likert Questions That Probe Participant Drop Preferences¹⁸

Question	Unit-Dose Drops	Multi-Dose Drops
1. Overall, how would you rate the delivery system compared to your habitual eye drops?	Much Better: 6%	Much Better: 17%
	Better: 47%	Better: 25%
	Same: 24%	Same: 42%
	Less: 6%	Less: 17%
	Much Less: 0%	Much Less: 0%
	Not Applicable: 18%	Not Applicable: 0%
2. Overall, how would you rate the delivery system compared to last week’s eye drops?	Much Better: 33%	Much Better: 18%
	Better: 25%	Better: 24%
	Same: 17%	Same: 18%
	Less: 25%	Less: 29%
	Much Less: 0%	Much Less: 12%
3. Overall, are you satisfied with your current drop delivery system?	Very Satisfied: 31%	Very Satisfied: 28%
	Satisfied: 45%	Satisfied: 38%
	Same: 14%	Same: 24%
	Unsatisfied: 10%	Unsatisfied: 10%
	Very Unsatisfied: 0%	Very Unsatisfied: 0%
4. Based on your satisfaction, are you going to carry on using the delivery system?	Yes: 14%	Yes: 21%
	Probably Yes: 41%	Probably Yes: 59%
	Probably No: 45%	Probably No: 17%
	No: 0%	No: 3%
5. Is the current drop delivery system easy to open?	Very Easy: 59%	Very Easy: 62%
	Easy: 41%	Easy: 38%
	Difficult: 0%	Difficult: 0%
	Very Difficult: 0%	Very Difficult: 0%
6. How do you consider the handling of the current delivery system?	Very Easy: 52%	Very Easy: 38%
	Easy: 48%	Easy: 52%
	Difficult: 0%	Difficult: 10%
	Very Difficult: 0%	Very Difficult: 0%
7. How easy is it for you to target your eye with the current delivery system?	Very Easy: 45%	Very Easy: 28%
	Easy: 52%	Easy: 48%
	Difficult: 0%	Difficult: 17%
	Very Difficult: 3%	Very Difficult: 7%
8. How easy is it for you to remove the residual drops from the current delivery system?	Very Easy: 41%	Very Easy: 10%
	Easy: 48%	Easy: 79%
	Difficult: 10%	Difficult: 10%
	Very Difficult: 0%	Very Difficult: 0%
9. Is it easy to squeeze and obtain the drop from your current delivery system?	Very Easy: 52%	Very Easy: 28%
	Easy: 45%	Easy: 48%
	Difficult: 3%	Difficult: 24%
	Very Difficult: 0%	Very Difficult: 0%
10. Is it easy to instill a drop with the current delivery system?	Very Easy: 41%	Very Easy: 34%
	Easy: 59%	Easy: 55%
	Difficult: 0%	Difficult: 10%
	Very Difficult: 0%	Very Difficult: 0%
11. Is the current drop installation method environmentally friendly?	Yes: 14%	Yes: 48%
	Probably Yes: 31%	Probably Yes: 38%
	Probably No: 38%	Probably No: 14%
	No: 17%	No: 0%

Notes: Questions 1 and 2 were only answered by half of the participants, because these questions depend upon when the participants started the drops (week 1 vs week 2). Adapted from Denis P, Duch S, Chen E et al. European real-world data about the use of a new delivery system containing a preservative-free multi-dose glaucoma treatment. Eur J Ophthalmol 2020;1120672120919342. Creative Commons.¹⁸

Denis P, Duch S, Chen E, et al. European real-world data about the use of a new delivery system containing a preservative-free multi-dose glaucoma treatment. Eur J Ophthalmol. 2020;1:1120672120919342.

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