Effect of Contact Lens Solutions in Stabilizing the Activity of Tear Lysozyme

Figures & data

Table 1 Contact Lens Solutions Evaluated

Material	Manufacturer’s Solution Description	Brand Name	Manufacturer
Nelfilcon A^Citation31	Phosphate-acetate buffered saline with comfort additives hydroxy-propylmethyl cellulose (HPMC) and polyethylene glycol 400 (PEG 400) and poloxamer 108	Dailies Aqua Comfort Plus	Alcon (Ft. Worth, TX)
Delefilcon A^Citation32	Phosphate buffered saline solution (PBS) with approximately 0.3% of polymeric wetting agents consisting of copolymers of polyamidoamine and poly (acrylamide-acrylic) acid	Dailies Total1
Verofilcon A^Citation33		Precision1
Kalifilcon A^Citation34	Phosphate buffered saline solution with potassium chloride, poloxamine 1107, poloxamer 181, glycerin, and erythritol	Infuse	Bausch & Lomb Incorporated (Rochester, NY)
Somofilcon A^Citation35	Borate Buffered Saline Solution containing 0.005% w/v Poloxamer 407	Clariti-1 day	CooperVision (Pleasanton, CA)
Stenfilcon A ^Citation36	Phosphate Buffered Saline Solution with Tween	MyDay
Etafilcon A^Citation37	Buffered saline solution with povidone	1-day Acuvue MOIST with Lacreon	Johnson & Johnson Vision Care, Inc. (Jacksonville, FL)
Narafilcon A^Citation38	Buffered saline solution with methyl ether cellulose	1-day Acuvue TruEye with Hydraclear
Senofilcon A^Citation39		Acuvue 1-day Oasys with HydraLuxe

Figure 1 Lysozyme activity assay.

Notes: Active native lysozyme image courtesy of Biological Magnetic Resonance Data Bank (2020, October 7). BMRB Featured System: Lysozyme. https://bmrb.io/featuredSys/Lysozyme/, used with permission. CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.⁴²

Figure 2 Lysozyme activity retained after addition of detergent in the presence of contact lens blister package solutions. Lysozyme stabilization expressed as percentage of activity retained after exposure of the protein to sodium lauryl sulfate in the presence of the respective CL solutions. *Significantly different from PBS control at p < 0.05.

Alcon Laboratories, Inc. (Fort Worth, TX). FOCUS® DAILIES®, FOCUS® DAILIES® Toric, FOCUS® DAILIES® Progressives, DAILIES® AquaComfort Plus®, DAILIES® AquaComfort Plus® Toric and DAILIES® AquaComfort Plus® Multifocal (nelfilcon A) one-day contact lenses [package insert]; 2013. Available from: https://2.myalcon.com/sites/g/files/rbvwei471/files/2019-04/W92024162_I_NELFILCON_A.pdf. Accessed April 4, 2023.

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