The Effect of Platelet-Rich Plasma on Type I Collagen Production, VEGF Expression, and Neovascularization after Femoral Bone Implants: A Study on Rat Models

Figures & data

Figure 1 K-wire implantation in femoral bone.

Table 1 Type I collagen numbers in groups T1 and C1

IHC (40× magnification)	T1 (n=6)		C1 (n=6)		p
	n	%	n	%
0–49 /field of view	0		5	83.3	0.003*
50–99 /field of view	1	16.7	1	16.7
100–149 /field of view	4	66.7	0
>150 /field of view	1	16.7	0
Total	6	100	6	100

Note: *Mann–Whitney test.

Figure 2 (A) Expression of type I collagen in tissue around implant with weak appearance; (B) expression of type I collagen in tissue around implant with moderate appearance; (C) expression of type I collagen in tissue around implants with strong appearance.

Table 2 VEGF expression and vascularization formation in groups T2 and C2

	T2	C2	p
VEGF expression* (mean ± SD)	10.90±4.47	2.29±0.92	0.006^a
Number of vessels on fibrotic capsule** (mean ± SD)	2.69±1.03	0.67±0.52	0.007^b

Notes: *ELISA; **histopathology examination; ^aindependent t-test; ^bMann–Whitney test.

Figure 3 Histology of blood vessels in fibrotic capsule in tissue surrounding implants. (A) Implant treatment group+ PRP group (40×); (B) implant treatment group (40×).