High expression of Sox10 correlates with tumor aggressiveness and poor prognosis in human nasopharyngeal carcinoma

Figures & data

Figure 1 Sox10 expressed in NPC tissue and adjacent nasopharyngeal tissue.

Notes: (A and B) Only a small amount of Sox10 expression in adjacent nasopharyngeal epithelial cells (final score 4; magnification ×200 and ×400, respectively; hematoxylin). (C and D) Low Sox10 expression in nasopharyngeal carcinoma tissue (final score 11; magnification ×200 and ×400, respectively; hematoxylin). (E and F) High Sox10 expression in nasopharyngeal carcinoma tissue (final score 240; magnification ×200 and ×400, respectively; hematoxylin).
Abbreviation: NPC, nasopharyngeal carcinoma.

Table 1 Correlation between Sox10 expression and clinicopathologic characteristics of NPC

Characteristics	Sox10 expression		Chi-square test
	Low expression	High expression	P-value
Age (years)			0.277
≤50	40	37
>50	11	17
Sex			0.404
Male	32	39
Female	19	15
Clinical stage			0.032
I	3	0
II	19	12
III	19	32
IV	10	10
T classification			0.034
T1	9	2
T2	28	30
T3	5	13
T4	9	9
N classification			0.138
N0	10	7
N1	25	18
N2	15	28
N3	1	1
N0-1 vs N2-3			0.03
N0-1	35	25
N2-3	16	29

Abbreviation: NPC, nasopharyngeal carcinoma.

Figure 2 Survival analysis of 105 NPC patients by Kaplan–Meier method.

Note: Survival curves of NPC patients with low expression versus high expression of Sox10 (P=0.004, log-rank test).
Abbreviation: NPC, nasopharyngeal carcinoma.

Table 2 Univariate and multivariate statistical analyses for various prognostic parameters in NPC patients

Characteristics	N	Univariate analysis		Multivariate analysis
		P-value	Regression coefficient (SE)	P-value	Relative risk	95% CI
Expression of Sox10		0.005*	0.901 (0.323)	0.011*	2.3	1.215–4.353
Low expression	54
High expression	51
Age (years)		0.027*	0.697 (0.315)	0.068	1.784	0.958–3.322
≤50	77
>50	28
Sex		0.113	−0.552 (0.348)
Male	71
Female	34
Clinical stage		0.11	0.318 (0.199)
I	3
II	31
III	51
IV	20
T classification		0.095	0.262 (0.157)
T1	11
T2	58
T3	18
T4	18
N classification		0.425	0.161 (0.202)
N0	17
N1	43
N2	43
N3	2
N0-1 vs N2-3		0.78	0.048 (0.301)
N0-1	60
N2-3	45

Note:

* Represents statistical significance.

Abbreviations: SE, standard error; CI, confidence interval.