B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer

Figures & data

Table 1 Major studies performed about the clinical significance of BMI1 in EOC

Study	Sample	Method	Clinical significance
Abd El hafez and El-Hadaad^Citation19	40 cancer tissues	IHC	High BMI1 expression strongly associated with advanced FIGO stages, bilaterality, and higher Gynecologic Oncology Group grades and carcinomas of serous histology. BMI1 expression displayed a significant inverse association with OS.
Zhang et al^Citation31	47 cancer tissues	IHC	BMI1 expression levels in ovarian carcinoma tissue differ depending on tissue grade (higher for G3 cancer cases than for grade G2 cases) and the stage of the disease (lower for Phase II and III than for Phase IV cases).
Yang et al^Citation39	179 ovarian carcinomas	IHC, FISH	Significant positive associations were found between intensive expression of BMI1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages. BMI1 expression was an independent prognostic factor for survival.
Gui et al^Citation42	100 primary ovarian tumors; 50 LN and recurrent tumors	IHC, TMA	BMI1 was heterogeneously expressed in primary versus recurrent tumors. Intensive expression of BMI1 in the first-onset lymph node metastases and recurrent tumors was associated with shortened PFS and shortened OS, respectively.

Abbreviations: BMI1, B-cell-specific Moloney murine leukemia virus integration site 1; EOC, epithelial ovarian cancer; FIGO, International Federation of Gynecologic Oncology; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; LN, lymph node; OS, overall survival; PFS, progression-free survival; TMA, tissue microarray.

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