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Original Research

Clinicopathological significance of ZEB-1 and E-cadherin proteins in patients with oral cavity squamous cell carcinoma

, , , , &
Pages 781-790 | Published online: 13 Feb 2017

Figures & data

Table 1 Clinicopathological characteristics of 120 OSCC patients

Figure 1 Representative images showing immunohistochemical staining for ZEB-1 and E-cadherin proteins in oral cavity squamous cell carcinoma (magnification ×200).

Notes: Negative ZEB-1 expression (A) and positive E-cadherin expression (B) in normal tissue, negative ZEB-1 expression (C) and positive E-cadherin expression (D) in well differentiated tumor, positive ZEB-1 expression (E, G) and negative E-cadherin expression (F, H) in poorly differentiated tumor and the ITF. The scale bar represents 50 μm.
Abbreviations: ZEB-1, zinc-finger E-box binding homeobox 1; ITF, invasive tumor front.
Figure 1 Representative images showing immunohistochemical staining for ZEB-1 and E-cadherin proteins in oral cavity squamous cell carcinoma (magnification ×200).

Figure 2 The relative expression levels of ZEB-1 and E-cadherin mRNA.

Notes: (A) ZEB-1 mRNA in OSCC was significantly higher than that in adjacent noncancerous tissues; (B) E-cadherin mRNA expression was lower in OSCC than in adjacent noncancerous tissues. *P<0.05.
Abbreviations: ZEB-1, zinc-finger E-box binding homeobox 1; E-cad, E-cadherin; OSCC, oral cavity squamous cell carcinoma.
Figure 2 The relative expression levels of ZEB-1 and E-cadherin mRNA.

Table 2 Clinicopathologic correlation of ZEB-1 and E-cadherin expression in OSCC

Table 3 Univariate and multivariate analysis of factors affecting overall survival

Figure 3 Kaplan–Meier survival curve for overall survival according to each immunohistochemical staining group and different clinical factors.

Notes: (A and B) shows the overall survival curves after surgery according to ZEB-1 and E-cadherin expression; (C) displays the 5-year overall survival rates were significantly poorer in the ZEB-1 positive and loss of E-cadherin expression group than in other expression groups; (DF) shows that patients with moderate/poor differentiation, lymph node metastasis and recurrence have worse prognosis.
Abbreviation: ZEB-1, zinc-finger E-box binding homeobox 1.
Figure 3 Kaplan–Meier survival curve for overall survival according to each immunohistochemical staining group and different clinical factors.

Figure S1 Representative images showing immunohistochemical staining for ZEB-1 and E-cadherin protein in the ITF of oral cavity squamous cell carcinoma (magnification ×200).

Abbreviation: ITF, invasive tumor front.

Figure S1 Representative images showing immunohistochemical staining for ZEB-1 and E-cadherin protein in the ITF of oral cavity squamous cell carcinoma (magnification ×200).Abbreviation: ITF, invasive tumor front.