Relationship between computed tomography morphology and prognosis of patients with stage I non-small cell lung cancer

Figures & data

Figure 1 The computed tomography morphological features of patients with stage I non-small cell lung cancer.

Notes: (A) The lesion in the right lower lobe showed homogeneous density and smooth and regular margins. (B) The density of the right lower lobe was heterogeneous. (C) Vacuole was observed in the posterior segment lesion of the right upper lobe. (D) Cavity was noted in the lesion of the right lower lobe. (E) The lingual segment lesion of the left upper lobe presented as a lobulation sign. (F) The margin of the left lower lobe was not smooth and showed an obvious short burr. (G) A halo sign was observed in the tumor periphery of the lesion. (H) Vessel convergence was noted in the tumor periphery of the lesion of the right middle lobe. (I) Bronchial transection was observed in the posterior segment lesion of the right upper lobe. (J) The surrounding bronchial vascular bundles of the right lower lobe lesion were thickened. (K) Adjacent pleura of the right upper lobe lesion showed indentation.

Figure 2 Survival curve of stage I non-small cell lung cancer patients with different tumor node metastasis stages.

Table 1 The relationships of CT morphological features with 5-year survival rates of patients with stage I non-small cell lung cancer

Feature	n	5-Year survival number (n)	5-Year survival rate (%)	MST	P-value
TNM staging					<0.001
T1a	37	33	89.19	60
T1b	44	33	75.00	60
T2a	43	18	41.86	49
Tumor density					0.346
Homogeneity	38	26	68.42	60
Inhomogeneity	43	31	72.09	60
Vacuole	37	22	59.46	56
Cavity	6	5	83.33	60
Tumor margin					<0.001
Slick margin	12	10	83.33	60
Lobulation sign	74	59	79.73	60
Short burr	38	15	39.47	45
Pleural invasion					<0.001
Normal	83	68	81.93	60
Pleural thickening/indentation	41	16	39.02	45
Tumor periphery					0.045
Normal	32	27	84.38	60
Halo	11	8	72.73	60
Vessel convergence	39	28	71.79	60
Bronchial transection	25	13	52.00	58
Vascular bundle thickening	17	8	47.06	56

Abbreviations: CT, computed tomography; MST, median survival time; TNM, tumor node metastasis.

Figure 3 Survival curve of stage I non-small cell lung cancer patients with different computed tomography features of tumor density.

Figure 4 Survival curve of stage I non-small cell lung cancer patients with different computed tomography features of tumor margin.

Figure 5 Survival curve of stage I non-small cell lung cancer patients with different computed tomography features of tumor periphery.

Figure 6 Survival curve of stage I non-small cell lung cancer patients with different computed tomography features of pleural invasion.

Table 2 Cox regression analysis of prognostic factors for stage I non-small cell lung cancer

Factor	RR	95% CI		P-value
		UL	LL
TNM staging
T1b vs T1a	2.905	0.794	10.621	0.107
T2a vs T1a	8.410	2.261	31.238	0.001
Tumor margin
Lobulation vs smooth	0.414	0.048	3.544	0.421
Short burr vs smooth	0.543	0.099	2.978	0.482
Pleural invasion
Pleural thickening and indentation vs normal	4.842	1.124	20.860	0.034
Tumor periphery
Halo vs normal	4.115	0.922	18.377	0.064
Vessel convergence vs normal	2.652	0.906	7.761	0.075
Bronchial transection vs normal	2.536	0.887	7.254	0.083
Vascular bundle thickening vs normal	2.911	0.915	9.261	0.070

Abbreviations: CI, confidence interval; LL, lower limit; RR, risk ratio; UL, upper limit.