Basal oxidative stress ratio of head and neck squamous cell carcinomas correlates with nodal metastatic spread in patients under therapy

Figures & data

Table 1 Characteristics of 36 patients

Parameters	Number of patients
Gender
Male	30
Female	6
Age, years
Median (range)	59 (47–81)
Nodal stage
N0	20
N1/N2/N3	16
T-stage
T1/T2	14
T3/T4	22
Disease stage
I–II	9
III–IV	27
Tumor site
Hypopharynx	8
Oropharynx	4
Pharynx	9
Larynx	15
Treatment
RT	10
RT + CT	17
No adjuvant treatment	9
Redox potential
Mean GSSG/GSH tumor (range)	6.69 (0.88–46.6)

Abbreviations: RT, radiotherapy; RT + CT, concomitant chemoradiotherapy; GSSG/GSH, oxidized/reduced glutathione.

Figure 1 Box plot showing the mean values of the ratio of oxidized and reduced glutathione (GSSG/GSH) (with 95% confidence interval) for nodal stages indicated (N0 versus N1/N2/N3), P=0.05.

Table S1 Distribution of patients according to nodal stage

N-stage	N0	N1/N2/N3	Total
Number of patients (n)	20	16	36
Age, years
Mean	61.8	57.8
Gender
Male	18	12	30
Female	2	4	6
Localization
Larynx	10	5	15
Hypopharynx	2	6	8
Pharynx	4	5	9
Oropharynx	4	0	4
T-stage
T1/T2	10	4	14
T3/T4	10	12	22
Disease stage
I–II	10	4	14
III–IV	10	12	22
Tumor site
Larynx	10	5	15
Hypopharynx	2	6	8
Pharynx	4	5	9
Oropharynx	4	0	4
Redox potential
Mean GSSG/GSH tumor	4.3	9.5	6.6

Abbreviation: GSSG/GSH, oxidized and reduced glutathione.