Correlation of SASH1 expression and ultrasonographic features in breast cancer

Figures & data

Figure 1 Ultrasonographic features of the patients with breast cancer.

Notes: (A) Edge burr sign. (B) Internal calcification. (C) Lymph node metastasis. (D) Blood flow grade III.

Figure 2 The expression of SASH1 in breast cancer.

Notes: (A) The positive expression of SASH1 was mainly observed in cytoplasm; (B) there was very little expression of SASH1 in negative samples. Original magnification ×400.

Table 1 Expression of SASH1 in benign and malignant breast diseases

Patients	Subjects (n)	SASH1^+	SASH1^−	SASH1^+ rate (%)	χ^2	P-value
Control	50	31	19	62.0	13.010	<0.001
Breast cancer	186	63	123	33.9	2.421	0.298
Infiltrating ductal carcinoma	153	48	105	31.4
Invasive lobular carcinoma	18	8	10	44.4
Invasive cribriform carcinoma and mucinous carcinoma	15	7	8	46.7

Note: ⁺, SASH1 positive expression; ⁻, negative expression.

Table 2 Relationship between SASH1 expression and ultrasonographic features in breast cancer

Ultrasonographic features	Subjects (n)	SASH1^+	SASH1^−	SASH1^+ rate (%)	χ^2	P-value
Tumor size					0.254	0.614
≥2 cm	75	27	48	36.0
<2 cm	111	36	75	32.4
Edge burr sign					5.024	0.025
Yes	118	33	85	28.0
No	68	30	38	44.1
Shape					1.310	0.252
Regular	33	14	19	42.4
Irregular	153	49	104	32.0
Internal calcification					0.212	0.645
Yes	90	29	61	32.2
No	96	34	62	35.4
Lymph node metastasis					7.162	0.007
Yes	105	27	78	25.7
No	81	36	45	44.4
Back echo					0.107	0.743
Attenuation	47	15	32	31.9
No attenuation	139	48	91	34.5
Blood flow grade					6.108	0.013
III	99	24	75	24.2
I–II	87	39	48	44.8

Note: ⁺, SASH1 positive expression; ⁻, negative expression.

Table 3 The expression of SASH1 correlates with edge burr sign, lymph node metastasis, and blood flow grade

Ultrasonographic features	r	95% CI	R^2	P-value
Tumor size	0.037	−0.119, 0.176	0.0014	0.616
Edge burr sign	−0.164	−0.314, −0.003	0.0269	0.025
Shape	0.084	−0.078, 0.237	0.0071	0.255
Internal calcification	−0.034	−0.184, 0.114	0.0012	0.648
Lymph node metastasis	−0.196	−0.333, −0.042	0.0384	0.007
Back echo	−0.024	−0.164, 0.121	0.0006	0.745
Blood flow grade	−0.217	−0.369, −0.078	0.0471	0.003