Skin toxicity evaluation in patients treated with cetuximab for metastatic colorectal cancer: a new tool for more accurate comprehension of quality of life impacts

Figures & data

Figure 1 Skin lesion score according to the Eruption Score System.

Table

I	Forehead	2
II	Cheek	3
III	Chin	2
IV	Upper chest	2
V	Lower chest	1
VI	Upper back	2
VII	Lower back	1

Table

Paronychia (Ps) mild +1

moderate +5

severe +7

Table

Blepharitis (Bs) mild +1

moderate +5

severe +7

Table

1	No toxicity
1–10	Very mild
16	Mild
30	Moderate
30–40	Severe
>41	Very severe

Table 1 Baseline demographic and clinical characteristics of patients enrolled in the study

Variables
Age (years), median (range)	59.6 (36.0–77.0)
Race, n (%)
Caucasian	30 (100.0)
Gender, n (%)
Male	20 (66.7)
Female	10 (33.3)
Primitive cancer site, n (%)
Colon	22 (73.3)
Rectum	8 (26.7)
History of rosacea, n (%)
Yes	11 (36.6)
No	19 (63.4)
Skindex-17, median (IQR)	56.7 (20.0–92.5)
Skindex-29, median (IQR)	68.1 (53.1–127.1)

Abbreviation: IQR, interquartile range.

Figure 2 Correlation between QoL evaluated with the Skindex-29 and severity of cutaneous toxicity assessed using NCI-CTCAE v4.0 and ESS systems.

Abbreviations: ESS, Eruption Scoring System; NCI-CTCAE, National Cancer Institute’s Common Terminology Criteria for adverse events; QoL, quality of life.

Figure 3 Correlation between QoL evaluated with the Skindex-17 and severity of cutaneous toxicity assessed using NCI-CTCAE v4.0 and ESS systems.

Abbreviations: ESS, Eruption Scoring System; NCI-CTCAE, National Cancer Institute’s Common Terminology Criteria for adverse events; QoL, quality of life.

Table 2 Median and IQR of each observer for NCI-CTCAE v4.0 and ESS

	Dermatologists						Oncologists
	Obs #1	Obs #2	Obs #3	Obs #4	Obs #5	Obs #6	Obs #7	Obs #8	Obs #9	Obs #10	Obs #11
NCI-CTCAE v4.0
Median	2.0	1.0	2.0	1.0	1.0	1.0	1.0	2.0	2.0	2.0	2.0
IQR	0–2.0	0–2.0	0–3.0	1.0–2.0	1.0–2.0	1.0–2.0	0–2.0	1.0–2.0	1.0–2.0	1.0–3.0	0–3.0
ESS
Median	27.0	20.0	29.0	29.0	27.0	27.0	15.0	28.0	24.0	26.0	25.0
IQR	0–35.0	0–36.0	5.0–43.0	0–36.0	10.0–41.0	3.0–42.0	0–28.0	0–37.0	0–34.0	0–36.0	0–37.0

Abbreviations: ESS, Eruption Scoring System; IQR, interquartile range; NCI-CTCAE, National Cancer Institute’s Common Terminology Criteria for Adverse Events; Obs, Observer.

Figure 4 Correlation between NCI-CTCAE v4.0 and ESS.

Abbreviations: ESS, Eruption Scoring System; NCI-CTCAE, National Cancer Institute’s Common Terminology Criteria for Adverse Events.