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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study

Jiao Yang1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Shuting Li1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Meng Lv1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Yinying Wu1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Zheling Chen1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Yanwei Shen1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Biyuan Wang1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Ling Chen1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China
,
Min Yi1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China;2 Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
&
Jin Yang1 Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1535-1548 | Published online: 13 Mar 2017

Figures & data

Table 1 Baseline characteristics of patients with subsequent primary malignancies development after colorectal cancer

Figure 1 Site distribution of subsequent primary malignancies.

Notes: The dashed vertical reference line (SIR 1) indicates similar risk of subsequent primary malignancies compared with the general population. The error bars indicate the 95% confidence interval of SIR. The risk increased mainly for subsequent primary cancers of the small intestine, ureter, colorectum, renal pelvis, endocrine system, and stomach (all SIRs >1), but decreased for the gallbladder, liver, myeloma, and brain, as well as lymphoma compared with the general population (all SIRs <1).
Abbreviation: SIR, standardized incidence interval.
Figure 1 Site distribution of subsequent primary malignancies.

Figure 2 Risk varied by latency for subsequent primary malignancies in all sites.

Note: Overall risk increased mainly in the initial 5 years after primary diagnosis.
Abbreviation: SIR, standardized incidence interval.
Figure 2 Risk varied by latency for subsequent primary malignancies in all sites.

Figure 3 Risk varied by age for subsequent primary malignancies of all sites and all solid tumors.

Note: A strong inverse relationship was observed between SIR and age of primary colorectal cancer diagnosis.
Abbreviation: SIR, standardized incidence interval.
Figure 3 Risk varied by age for subsequent primary malignancies of all sites and all solid tumors.

Figure 4 Risk varied by sex for subsequent primary malignancies in different sites.

Note: Overall risk for subsequent primary malignancies and sites at high cancer risk were different between women and men with prior colorectal cancer.
Abbreviation: SIR, standardized incidence interval.
Figure 4 Risk varied by sex for subsequent primary malignancies in different sites.

Figure 5 Risk varied by subsites of prior colorectal cancer for subsequent primary malignancies in different sites.

Notes: An inverse relationship was indicated between overall SIR and subsites of primary diagnosis: 1.09 in right-sided colon cancer, 1 in left-sided colon cancer, and 0.93 in rectal cancer. Patients with different prior colorectal cancer subsites showed specific sites at high cancer risk.
Abbreviation: SIR, standardized incidence interval.
Figure 5 Risk varied by subsites of prior colorectal cancer for subsequent primary malignancies in different sites.

Table 2 Risk of subsequent primary malignancies among colorectal cancer survivors stratified by sex, age, and prior tumor location

Table S1 Risk of subsequent primary malignancies grouped by radiotherapy among patients with rectal cancer

Table S2 Risk of subsequent primary malignancies grouped by year of prior colorectal cancer diagnosis

Table S3 Risk of subsequent primary malignancies grouped by race among patients with prior colorectal cancer

Table S4 Risk of subsequent primary malignancies grouped by SEER summary stage of prior colorectal cancer

Table S5 Risk of subsequent primary malignancies grouped by grade of prior colorectal cancer

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