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OncoTargets and Therapy Volume 10, 2017 - Issue
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Review

Role of cytokines and chemokines in alcohol-induced tumor promotion

Danlei Chen1 School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China
,
Fengyun Zhang1 School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China
,
Haifeng Ren1 School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China
,
Jia Luo2 Department of Pharmacology and Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY, USA
&
Siying Wang1 School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaCorrespondence[email protected]
Pages 1665-1671 | Published online: 17 Mar 2017

Figures & data

Figure 1 Role of VEGF and MCP-1 in alcohol-induced tumor growth and metastasis.

Notes: Alcohol exposure upregulates VEGF level, thus promoting angiogenesis of endothelial cells. Alcohol exposure activates MCP-1 and recruits M2 macrophages, which, in turn, promotes the growth and metastasis of cancer cells.
Figure 1 Role of VEGF and MCP-1 in alcohol-induced tumor growth and metastasis.

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