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Case Report

Apatinib to combat EGFR-TKI resistance in an advanced non-small cell lung cancer patient with unknown EGFR status: a case report

, , , , , , , & show all
Pages 2289-2295 | Published online: 26 Apr 2017

Figures & data

Figure 1 Tumor section staining with hematoxylin and eosin (400×).

Figure 1 Tumor section staining with hematoxylin and eosin (400×).

Figure 2 Thoracic computed tomography (CT) showing a mass in the left upper lobe before taking apatinib (A), an obvious cavitation in the mass (B), mass increasing after apatinib suspension for 6 days (C), cavitation extending gradually with added dose of apatinib via monthly CT examination (D and E), and an overall increase of mass despite the larger cavitation (F). The red arrows indicate specific region of tumor.

Figure 2 Thoracic computed tomography (CT) showing a mass in the left upper lobe before taking apatinib (A), an obvious cavitation in the mass (B), mass increasing after apatinib suspension for 6 days (C), cavitation extending gradually with added dose of apatinib via monthly CT examination (D and E), and an overall increase of mass despite the larger cavitation (F). The red arrows indicate specific region of tumor.

Figure 3 Cranial MRI showing the encephaledem in the occipital lobe of the head (A), encephaledem obviously alleviating (B), slightly worsening after suspension of apatinib for 6 days (C), the encephaledem basically under control as shown by CT every 2 months (D and E).

Abbreviations: MRI, magnetic resonance imaging; CT, computed tomography.
Figure 3 Cranial MRI showing the encephaledem in the occipital lobe of the head (A), encephaledem obviously alleviating (B), slightly worsening after suspension of apatinib for 6 days (C), the encephaledem basically under control as shown by CT every 2 months (D and E).

Table 1 Medication of apatinib combined with erlotinib

Figure 4 The venous blood routine from anticoagulant therapy.

Figure 4 The venous blood routine from anticoagulant therapy.

Figure 5 The activated partial thromboplastin time from anticoagulant therapy.

Figure 5 The activated partial thromboplastin time from anticoagulant therapy.

Figure 6 The subcutaneous hemorrhage in limbs on August 31, 2016.

Figure 6 The subcutaneous hemorrhage in limbs on August 31, 2016.