GSTM1 polymorphism is related to risks of nasopharyngeal cancer and laryngeal cancer: a meta-analysis

Figures & data

Figure 1 Article selection process. 32 eligible articles were included into the present meta-analysis.

Abbreviation: CNKI, China National Knowledge Infrastructure.

Table 1 Basic information of included articles

Cancers	Author	Year	Country	Method	Score	Case		Control
						Present	Null	Present	Null
LC	Unal et al^Citation26	2004	Turkey	Real-time PCR	5	23	19	57	32
	Gajecka et al^Citation27	2005	Poland	PCR-RFLP	7	152	140	157	164
	Acar et al^Citation28	2006	Turkey	PCR	8	53	57	123	74
	To-Figueras et al^Citation29	2002	Spain	PCR-RFLP	8	108	96	103	100
	Hong et al^Citation30	2000	Korean	PCR	8	26	56	30	33
	Charzimichalis et al^Citation31	2010	Greece	PCR	8	14	74	14	88
	Jourenkova et al^Citation32	1998	France	PCR	9	51	78	82	90
	Tian et al^Citation33	2011	China	PCR	8	117	116	80	22
	Lourenco et al^Citation34	2011	Brazil	PCR-RFLP	7	23	14	76	66
	Yan and Zhou^Citation35	2003	China	PCR	7	12	30	56	52
	Li et al^Citation36	2004	China	PCR	7	39	50	95	69
	Morita et al^Citation37	1999	Japan	PCR	7	39	81	30	83
	Kihara et al^Citation38	1997	Japan	PCR	8	70	86	242	230
	Bardakci et al^Citation39	2003	Turkey	PCR	8	11	25	19	16
	Gattas et al^Citation40	2006	Brazil	PCR-RFLP	8	12	10	63	39
	Lei et al^Citation41	2003	China	PCR	7	17	45	28	28
	Matthias et al^Citation42	2003	German	PCR	7	114	151	83	95
	Risch et al^Citation43	2003	German	PCR-RFLP	9	118	127	116	135
	Gronau et al^Citation44	2003	German	PCR	8	107	80	71	68
	Jahnke et al^Citation45	1997	German	PCR-RFLP	8	118	51	104	112
	Biselli et al^Citation46	2006	Brazil	PCR	8	15	7	31	29
NPC	Deng et al^Citation15	2004	China	PCR	7	35	56	71	64
	Jiang et al^Citation16	2011	China	PCR	7	85	97	215	157
	Cheng et al^Citation17	2003	China	PCR	8	141	173	168	169
	Guo et al^Citation18	2008	China	PCR	8	137	204	262	328
	Zhang^Citation19	2012	China	PCR-CTPP	7	18	27	19	11
	Da et al^Citation20	2002	China	PCR	8	32	48	44	36
	Wei et al^Citation21	2010	China	PCR	7	48	48	336	305
	Deng et al^Citation22	2005	China	PCR	7	49	78	112	95
	Tiwawech et al^Citation23	2005	Japan	PCR	7	28	50	71	74
	Liao et al^Citation24	2005	China	PCR	7	30	50	40	32
	Nazar-Stewart et al^Citation25	1999	America	PCR	8	38	45	79	63

Note: Quality assessment of each study was performed by the method of Newcastle-Ottawa Scale and the score was calculated.

Abbreviations: PCR, polymerase chain reaction; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; PCR-CTPP, polymerase chain-reaction with the confronting-two-pair primer; NPC, nasopharyngeal cancer; LC, laryngeal cancer.

Figure 2 Subgroup analysis by source of control about the association between GSTM1 null genotype and risk of LC.

Note: Weights are from random effects analysis.
Abbreviations: LC, laryngeal cancer; OR, odds ratio; CI, confidence interval; PB, population-based; HB, hospital-based.

Table 2 Pooled results of the present meta-analysis

Cancers	Subgroup	Types	OR	95% CI	P-value for heterogeneity
LC	Ethnicity	Caucasian	1.27	0.99–1.56	0.000
		Asian	1.36	0.96–1.93	0.053
	Source of	PB	1.13	0.86–1.48	0.022
	control	HB	1.38	1.06–1.80	0.000
	Total	–	1.28	1.05–1.54	0.000
NPC	Source of	PB	1.39	1.18–1.63	0.309
	control	HB	1.52	1.22–1.89	0.423
	Total	–	1.43	1.26–1.63	0.417

Abbreviations: LC, laryngeal cancer; NPC, nasopharyngeal cancer; OR, odds ratio; CI, confidence interval; PB, population-based; HB, hospital-based.

Figure 3 Subgroup analysis by source of control about the association between GSTM1 null genotype and risk of NPC.

Abbreviations: NPC, nasopharyngeal cancer; OR, odds ratio; CI, confidence interval; PB, population-based; HB, hospital-based.

Figure 4 Begg’s funnel plot (NPC). The funnel plot seemed to be symmetrical (P=0.436).

Abbreviations: NPC, nasopharyngeal cancer; OR, odds ratio; CI, confidence interval; SE, standard error.

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