Figures & data
Notes: Signaling through PD-1 induces T cell anergy, with the physiological role of protecting from autoimmune damage. This mechanism is exploited by tumor cells expressing PD-1 ligands to escape immunity by suppressing host antitumor T cell responses (left). PD-1 or PD-L1 blocking antibodies have the capability to restore cytotoxic T cell functions including IFN-y and perforin production, which can lead to impressive antitumor responses (right).
Abbreviations: PD, programmed cell death; PD-L1, programmed cell death receptor ligand-1.
Abbreviations: PD, programmed cell death; PD-L1, programmed cell death receptor ligand-1.