Novel insights into circular RNAs in clinical application of carcinomas

Figures & data

Figure 1 Mechanism of circRNAs functioning as competing endogenous RNAs or miRNA sponges.

Abbreviations: circRNAs, circular RNAs; miRNA, microRNA; mRNA, messenger RNA.

Table 1 Literature of circRNAs and carcinomas

Type of cancer	First author	Received date	Journal	Sequence name or more content	Expression
Cutaneous squamous cell carcinoma^Citation14	Sand M	2016/6/15	J Dermatol Sci	Picking out 322 circRNAs	cir-143↑, cir-179↓
BCC^Citation28	Sand M	2016/4/21	Epigenomics	Screening out 71 circRNAs	23 circRNAs↑, 48 circRNAs↓
Epithelial ovarian carcinoma^Citation29	Ahmed I	2016/4/28	Oncotarget	Altered expression pattern	Unclear
Ovarian carcinoma^Citation30	Bachmayr-Heyda A	2016/5/14	Oncotarget	Unclear	Unclear
Cervical cancer^Citation31	Abdelmohsen K	2017/1/13	RNA Biol	CircPABPN1 (hsa_circ_0031288)	Unclear
Laryngeal cancer^Citation27	Xuan L	2016/5/10	Am J Transl Res	hsa_circ_104912, hsa_circ_100855	hsa_circ_104912↓, hsa_circ_100855↑
Hepatoma carcinoma^Citation32	Qin M	2015/11/26	Cancer Biomark	hsa_circ_0001649	hsa_circ_0001649↓
Hepatoma carcinoma^Citation24	Yu L	2016/7/9	PLoS One	circRNA Cdr1	circRNA Cdr1↑
Hepatoma carcinoma^Citation25	Shang X	2016/6/4	Medicine (Baltimore)	hsa_circ_0000520, hsa_circ_0005075, hsa_circ_0066444	Unclear
Hepatoma carcinoma^Citation33	Xu L	2016/9/12	J Cancer Res Clin Oncol	ciRS-7 (Cdr1as)	ciRS-7 (Cdr1as)↓
Pancreatic ductal carcinoma^Citation34	Qu S	2015/10/21	Genom Data	Microarray expression profile	Unclear
Neuroglioma^Citation35	Song X	2016/2/14	Nucleic Acids Res	Screening out 476 circRNAs	Unclear
Neuroglioma^Citation36	Barbagallo D	2015/12/20	Oncotarget	Unclear	Unclear
Neuroglioma^Citation37	Yang P	2016/9/11	Oncotarget	cZNF292 circRNA	cZNF292 circRNA↓
Colorectal cancer^Citation38	Wang X	2016/2/18	Int J Clin Exp Pathol	hsa_circ_001988	hsa_circ_001988↓
Colorectal cancer, ovarian carcinoma^Citation39	Bachmayr-Heyda A	2015/1/28	Sci Rep	The percent of circ/line	The percent of circ/line↓
Colorectal cancer^Citation12	Xie H	2016/4/9	Oncotarget	hsa_circ_001569	hsa_circ_001569↑
Colorectal cancer^Citation40	Huang G	2015/6/26	PLoS One	cir-ITCH	cir-ITCH↓
Colorectal cancer^Citation41	Zhu M	2017/1/20	Biomed Pharmacother	circ-BANP	circ-BANP↑
KRAS mutant colon cancer^Citation42	Dou Y	2016/11/29	Sci Rep	circRNA	circRNA↓
Gastric carcinoma^Citation22	Li P	2015/2/18	Clin Chim Acta	hsa_circ_002059	hsa_circ_002059↓
Gastric carcinoma^Citation43	Li P	2017/1/13	Br J Cancer	hsa_circ_0000096	hsa_circ_0000096↓
Gastric carcinoma^Citation44	Chen S	2017/1/29	Clin Chim Acta	hsa_circ_0000190	hsa_circ_0000190↓
Esophageal carcinoma^Citation12	Xia W	2016/10/19	Sci Rep	hsa_circ_0067934	hsa_circ_0067934↑
Radio-resistant esophageal cancer^Citation45	Su H	2016/7/29	J Transl Med	hsa_circ_001059, hsa_circ_100385, hsa_circ_104983, hsa_circ_000167, hsa_circ_101877, hsa_circ_102913, hsa_circ_000695	hsa_circ_001059↑, hsa_circ_100385↑, hsa_circ_104983↑, hsa_circ_000167↓, hsa_circ_101877↓, hsa_circ_102913↓, hsa_circ_000695↓
Esophageal carcinoma^Citation21	Li F	2015/3/10	Oncotarget	cir-ITCH	cir-ITCH↓
Hematopoiesis malignancies^Citation46	Bonizzato A	2016/10/16	Blood Cancer J	Screening out the expression of circRNAs	Unclear
Bladder carcinoma^Citation26	Zhong Z	2016/8/4	Sci Rep	circTCF25	circTCF25↑
Bladder carcinoma^Citation47	Huang M	2016/7/1	Oncotarget	circRNA M, YLK	Unclear
Clear cell renal cell carcinoma^Citation48	Wang K	2017/1/17	Cancer Lett	circHIAT1	circHIAT1↓
Breast cancer^Citation49	Yang W	2015/12/15	Oncogene	Foxo3 circRNA	Foxo3 circRNA↑
Breast cancer^Citation50	Nair AA	2016/11/10	Oncotarget	Unclear	Unclear
Lung cancer^Citation23	Wan L	2016/9/20	Biomed Res Int	circRNA-ITCH	circRNA-ITCH↓
Seven cancers^Citation51	Zheng Q	2016/4/7	Nat Commun	circHIPK3	circHIPK3↓
Cancer^Citation52	Du WW	2016/2/11	Nucleic Acids Res	circ-Foxo3	circ-Foxo3↓
Cancer^Citation53	Hansen TB	2011/10/4	EMBO J	CDR1	Unclear
Carcinoma^Citation54	Du WW	2016/11/26	Cell Death Differ	circ-Foxo3	circ-Foxo3↓

Notes: ↓ means downregulated. ↑ means upregulated.

Abbreviations: circRNAs, circular RNA; BCC, basal cell carcinoma.

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