A systematic comparison of treatment modalities for nasal extranodal natural killer/T-cell lymphoma in early stages between concurrent chemoradiotherapy and sequential chemotherapy

Figures & data

Table 1 Clinical characteristics of patients with ENKTL, nasal type

Characteristics	CCRT (n=30)	SCRT (n=28)	χ^2 value	P-value
Sex			0.056	0.813
Male	17	15
Female	13	13
Age (years)			0.554	0.457
≤60	21	17
>60	9	11
ECOG performance status			1.353	0.336
0–1	22	24
≥2	8	4
Ann Arbor stage			0.322	0.571
IE	16	17
IIE	14	11
B symptoms			0.030	0.826
Yes	7	6
No	23	22
LDH level			1.283	0.325
Normal	26	21
Increased	4	7
Primary site			0.588	0.745
Left nasal cavity	12	14
Right nasal cavity	14	11
Bilateral nasal cavity	4	3
IPI score			0.433	0.805
0	17	15
1	11	12
2–3	2	1

Abbreviations: ENKTL, extranodal natural killer/T-cell lymphoma; CCRT, concurrent chemoradiotherapy; SCRT, sequential chemotherapy followed by radiotherapy; ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase; IPI, International Prognostic Index.

Figure 1 Comparison of overall survival between the CCRT and SCRT groups (P=0.029).

Abbreviations: CCRT, concurrent chemoradiotherapy; SCRT, sequential chemotherapy followed by radiotherapy.

Figure 2 Comparison of progression-free survival between the CCRT and SCRT groups (P=0.030).

Abbreviations: CCRT, concurrent chemoradiotherapy; SCRT, sequential chemotherapy followed by radiotherapy.

Figure 3 Comparison of locoregional-free survival between the CCRT and SCRT groups (P=0.026).

Abbreviations: CCRT, concurrent chemoradiotherapy; SCRT, sequential chemotherapy followed by radiotherapy.

Table 2 Patterns of failure for CCRT and SCRT group patients

Patterns of failure	CCRT, n	SCRT, n
Local relapse	6	12
In the nasal cavity	2	6
In laryngopharyngeal area	1	0
In nasopharyngeal	2	3
In the left maxillary sinus	1	3
Distant relapse	4	3
Liver	1	1
Breast	2	0
Lung	0	1
Skin	0	1
Colon	1	0

Abbreviations: CCRT, concurrent chemoradiotherapy; SCRT, sequential chemotherapy followed by radiotherapy.

Table 3 Adverse event grade by treatment group

Toxicity	CCRT				SCRT				χ^2 value	P-value
	1	2	3	4	1	2	3	4
Hematologic
Anemia	3	5	0	0	4	0	0	0	4.286	0.081
Leukopenia	11	8	6	5	12	10	5	0	5.213	0.157
Thrombocytopenia	6	4	0	0	5	1	0	0	0.950	0.330
Nonhematologic
Nausea	9	12	6	0	7	9	3	0	0.296	0.862
Vomiting	12	9	6	3	17	7	4	0	4.448	0.217
Mucositis	8	13	7	2	15	10	3	0	6.060	0.109

Abbreviations: CCRT, concurrent chemoradiotherapy; SCRT, sequential chemotherapy followed by radiotherapy.