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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

Clinical importance of serum HE4 and MMP2 levels in endometrial cancer patients

Aneta Cymbaluk-Płoska1 Department of Gynecological Surgery and Gynecological Oncology of Adults and AdolescentsCorrespondence[email protected]
,
Anita Chudecka-Głaz1 Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents
,
Ewa Pius-Sadowska2 Department of General Pathology, Pomeranian Medical University
,
Agnieszka Sompolska-Rzechuła3 Department of Statistics, West Pomeranian University of Technology, Szczecin, Poland
,
Bogusław Machaliński2 Department of General Pathology, Pomeranian Medical University
,
Anna Surowiec1 Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents
&
Janusz Menkiszak1 Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents
 show all
Pages 3169-3175 | Published online: 27 Jun 2017

Figures & data

Table 1 Patients with endometrial cancer divided into subgroups

Table 2 Comparative analysis of the study groups pre- vs post-menopausal

Table 3 Comparative analysis according to the prognostic factors for HE4

Table 4 Comparative analysis according to the prognostic factors for MMP2

Figure 1 The ROC curve for MMP2 protein in patients without division due to the hormonal status (AUC =0.79).

Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve.
Figure 1 The ROC curve for MMP2 protein in patients without division due to the hormonal status (AUC =0.79).

Figure 2 The ROC curve for HE4 protein in patients without division due to the hormonal status (AUC =0.92).

Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve.
Figure 2 The ROC curve for HE4 protein in patients without division due to the hormonal status (AUC =0.92).

Figure 3 The ROC curves for HE4 and MMP2 proteins in patients before menopause (AUC =0.92/0.84).

Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve.
Figure 3 The ROC curves for HE4 and MMP2 proteins in patients before menopause (AUC =0.92/0.84).

Figure 4 The ROC curves for HE4 and MMP2 proteins in post-menopausal women (AUC =0.86/0.71).

Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve.
Figure 4 The ROC curves for HE4 and MMP2 proteins in post-menopausal women (AUC =0.86/0.71).

Figure 5 The ROC curves for HE4 and MMP2 proteins depending on staging (AUC =0.86/0.82).

Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve.
Figure 5 The ROC curves for HE4 and MMP2 proteins depending on staging (AUC =0.86/0.82).

Figure 6 The ROC curves for HE4 and MMP2 proteins in G1 and G3 grading (AUC =0.82/0.74).

Abbreviations: ROC, receiver operating characteristic; AUC, area under the curve.
Figure 6 The ROC curves for HE4 and MMP2 proteins in G1 and G3 grading (AUC =0.82/0.74).

Table 5 Sensitivity and specificity values for HE4 and MMP2

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